Document Detail


Effects of left ventricular receptor stimulation on coronary blood flow in conscious dogs.
MedLine Citation:
PMID:  2822285     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The present study was undertaken to determine the effects of intracoronary administration of the veratrum alkaloid veratridine on coronary blood flow and resistance in conscious, chronically instrumented intact and sinoaortic denervated dogs. Ten dogs were instrumented with a Doppler flow probe on the left anterior descending coronary artery. A chronic catheter was placed in the left circumflex coronary artery and in the aorta and left atrium. A Konigsberg pressure cell was placed in the left ventricle, and pacing leads were attached to the left atrium and ventricle. While heart rate was kept constant, bolus intracoronary injections of veratridine (0.1-0.4 microgram/kg) were administered in the unblocked state after beta 1-receptor blockade, after alpha-receptor blockade, and after cholinergic blockade. In the unblocked state, late diastolic coronary resistance fell by 34.7 +/- 5.0%. The maximum response was achieved at a time when arterial pressure was not significantly different from control. After beta 1-blockade, coronary resistance fell by 29.1 +/- 7.9%. After combined alpha- and beta-blockade, coronary resistance fell by 25.4 +/- 6.5% in response to veratridine. The addition of atropine completely blocked the decrease in coronary resistance, changing it by an average of -0.10 +/- 2.5%. The responses in sinoaortic denervated dogs were similar to those in intact animals. The response was abolished by vagotomy. We conclude that cardiac receptor stimulation causes a reflex decrease in coronary resistance in the awake dog that is completely accountable by a cholinergic mechanism.
Authors:
I H Zucker; K G Cornish; J Hackley; K Bliss
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Circulation research     Volume:  61     ISSN:  0009-7330     ISO Abbreviation:  Circ. Res.     Publication Date:  1987 Nov 
Date Detail:
Created Date:  1987-12-15     Completed Date:  1987-12-15     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0047103     Medline TA:  Circ Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  II54-60     Citation Subset:  IM    
Affiliation:
Department of Physiology and Biophysics, University of Nebraska College of Medicine, Omaha 68105.
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MeSH Terms
Descriptor/Qualifier:
Animals
Atropine / pharmacology
Autonomic Nervous System / physiology*
Blood Flow Velocity / drug effects
Blood Pressure / drug effects
Coronary Circulation / drug effects*
Denervation
Dogs
Heart Ventricles / metabolism
Metoprolol / pharmacology
Phentolamine / pharmacology
Receptors, Adrenergic, alpha / physiology
Receptors, Adrenergic, beta / physiology
Receptors, Cholinergic / physiology*
Sinus of Valsalva / innervation
Vascular Resistance / drug effects
Veratridine / pharmacology*
Veratrine / analogs & derivatives*
Grant Support
ID/Acronym/Agency:
HL-33359/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Receptors, Adrenergic, alpha; 0/Receptors, Adrenergic, beta; 0/Receptors, Cholinergic; 37350-58-6/Metoprolol; 50-60-2/Phentolamine; 51-55-8/Atropine; 62-59-9/Veratrine; 71-62-5/Veratridine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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