| Effects of lecithin: Cholesterol acyltransferase genotypes, enzyme levels, and activity on high-density lipoprotein levels. | |
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MedLine Citation:
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PMID: 21600519 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND: Lecithin:cholesterol acyltransferase (LCAT) is one of the key enzymes controlling cholesterol homeostasis and plays a primary role in high-density lipoprotein cholesterol (HDL-C) maturation. OBJECTIVE: The aim of our study was to evaluate the effects of LCAT gene polymorphisms 511C/T (exon4), 4886C/T (rs5923), and 608C/T (rs5922) on LCAT enzyme level, activity, and HDL-C levels. METHODS: The study population was selected from consecutive subjects with low (<35 mg/dL) and high HDL-C levels (>65 mg/dL) seen in our lipid clinic. LCAT polymorphisms were analyzed with a restriction fragment length polymorphism assay. LCAT activity and levels were measured by colorimetric enzymatic and enzyme-linked immunoassay methods, respectively. RESULTS: The 4886C/T polymorphism was the most commonly observed variant of LCAT gene. T-allele frequencies in subjects with low (n = 50) and high (n = 50) HDL-C were 0.54 and 0.37, respectively (P = .019). TT genotype was more common among low HDL-C group (30% vs 14%, P = .05). The effects of LCAT enzyme appeared to depend on the HDL-C level. In subjects with low HDL-C, LCAT enzyme levels correlated positively with body mass index (P < .001, r = 0.544), HDL-C (P = .006, r = 0.404), triglycerides (P = .001, r = 0.487), total cholesterol (P < .001, r = 0.541), and low-density lipoprotein-cholesterol (P = .001, r = 0.477) levels. LCAT activity correlated positively with fasting glucose levels (P = .008, r = 0.390). CONCLUSION: LCAT genotype, enzyme level, and activity modulate HDL-C metabolism, particularly among subjects with low HDL-C levels. |
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Authors:
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Deniz Agirbasli; Beyazit Cirakoglu; Fatih Eren; Mutlu Sumerkan; Sukru Aksoy; Cenk Aral; Mehmet Agirbasli |
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Publication Detail:
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Type: Journal Article Date: 2011-03-01 |
Journal Detail:
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Title: Journal of clinical lipidology Volume: 5 ISSN: 1933-2874 ISO Abbreviation: J Clin Lipidol Publication Date: 2011 May-Jun |
Date Detail:
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Created Date: 2011-05-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101300157 Medline TA: J Clin Lipidol Country: United States |
Other Details:
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Languages: eng Pagination: 152-8 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 National Lipid Association. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Medical Biology and Genetics, Marmara University School of Medicine, Istanbul, Turkey; Department of Medical Biology, Acibadem University School of Medicine, Istanbul, Turkey. |
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