| Effects of latanoprost and timolol-XE on hydrodynamics in the normal eye. | |
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MedLine Citation:
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PMID: 11004288 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To compare the effects of latanoprost and timolol-XE on ocular pressure and perfusion in healthy adults, with respect to episcleral venous pressure. METHODS: A double-masked, placebo-controlled crossover study of weeklong bedtime treatment with one drop of drug, with placebo contralaterally, followed by a 3-week washout and alternate-drug/contralateral-placebo repeat. Intraocular pressure was measured by applanation and by pneumotonometry, providing pulsatile ocular circulatory estimates. Measurements of episcleral venous pressure were obtained (Friberg method). RESULTS: Twenty subjects participated (five men, 15 women; mean age, 39 years (range, 21 to 55 years); mean baseline intraocular pressure, 13.4 mm Hg). A greater decrease in intraocular pressure was seen among these subjects the morning after initiating treatment with latanoprost (-2.0 mm Hg; P <.0001) than with timolol-XE (-0.9 mm Hg; P =.051) (latanoprost versus timolol DeltaP =.008). This ocular hypotensive effect remained significant that evening with latanoprost (-3.2 mm Hg; P <.0001) but not with timolol XE (-1.0 mm Hg; P =.2). By the morning of day 8, mean intraocular pressure remained 3.2 mm Hg below baseline with latanoprost and 2.3 mm Hg below baseline with timolol-XE (P <.0001 for both drugs). Neither drug altered episcleral venous pressure. Among a subgroup of nine subjects with comparable intraocular pressure reductions with the two drugs, latanoprost treatment was associated with a 16.7% increase in mean pulsatile ocular blood flow (P =.04) through the weeklong treatment interval, consistently higher than during timolol-XE treatment of the same subjects. CONCLUSION: Latanoprost caused an overnight decrease in intraocular pressure in normotensive normal eyes, and both drugs significantly reduced intraocular pressure within 1 week. Intraocular pressure remained higher than episcleral venous pressure throughout treatment with both drugs. Latanoprost was associated with enhanced pulsatile ocular perfusion not seen with timolol-XE treatment. |
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Authors:
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W E Sponsel; J Mensah; J W Kiel; A Remky; Y Trigo; W Baca; T Friberg |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of ophthalmology Volume: 130 ISSN: 0002-9394 ISO Abbreviation: Am. J. Ophthalmol. Publication Date: 2000 Aug |
Date Detail:
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Created Date: 2000-10-26 Completed Date: 2000-11-01 Revised Date: 2013-01-31 |
Medline Journal Info:
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Nlm Unique ID: 0370500 Medline TA: Am J Ophthalmol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 151-9 Citation Subset: AIM; IM |
Affiliation:
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Department of Ophthalmology, University of Texas Health Science Center, San Antonio, Texas 78284-6230, USA. sponsel@earthlink.net |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Antagonists
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pharmacology* Adult Antihypertensive Agents / pharmacology* Circadian Rhythm / drug effects Cross-Over Studies Double-Blind Method Female Gels Humans Intraocular Pressure / drug effects* Male Middle Aged Ophthalmic Solutions / pharmacology Prostaglandins F, Synthetic / pharmacology* Pulsatile Flow / drug effects Sclera / blood supply Timolol / pharmacology* Tonometry, Ocular Venous Pressure / drug effects* |
| Grant Support | |
ID/Acronym/Agency:
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R01 EY009702/EY/NEI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists; 0/Antihypertensive Agents; 0/Gels; 0/Ophthalmic Solutions; 0/Prostaglandins F, Synthetic; 130209-82-4/latanoprost; 26839-75-8/Timolol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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