Document Detail


Effects of landiolol on systemic and cerebral hemodynamics and recovery from anesthesia in patients undergoing craniotomy.
MedLine Citation:
PMID:  20339879     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: Maintenance of systemic and cerebral hemodynamics and quick recovery from anesthesia are required for craniotomy. We conducted a prospective randomized study to investigate the effects of continuous infusion of landiolol on hemodynamic responses to various stimuli, changes in systemic and cerebral hemodynamics during anesthesia, and recovery from anesthesia in patients undergoing craniotomy.
METHODS: Thirty patients undergoing elective craniotomy were randomly divided into two groups: a landiolol group and a control (saline) group. Landiolol was administered as an infusion rate of 0.125 mg/kg/min for 1 min, followed by an infusion at 0.01-0.04 mg/kg/min until 6 h after the end of anesthesia. Maximal values of heart rate (HR) and systolic blood pressure (SBP) in response to tracheal intubation, pin fixation, the beginning of operation, and extubation were compared between groups. Tissue oxygen index (TOI), mean arterial pressure (MAP), cardiac index (CI), and stroke volume index (SVI) before, during, and at the end of operation were compared between groups. Total doses of fentanyl, interval for the recovery from anesthesia, and incidence of postoperative nausea and vomiting (PONV) were also compared.
RESULTS: Maximal values of HR at intubation and pin fixation and of HR and SBP at extubation were significantly less in the landiolol group compared with those in the control group. TOI, MAP, CI, and SVI were similar between groups during anesthesia. Total doses of fentanyl were significantly less in the landiolol group than in the control group. Interval for recovery from anesthesia and incidence of PONV were similar between groups.
CONCLUSION: This study indicates that continuous infusion of landiolol suppressed hyperdynamic responses to stimuli during anesthesia while maintaining arterial blood pressure and cerebral oxygen balance during craniotomy. Although landiolol infusion did not affect recovery from anesthesia and incidence of PONV, it reduced intraoperative requirement of fentanyl.
Authors:
Masahiko Kawaguchi; Yoshitaka Kawaraguchi; Yuri Yamamoto; Hironobu Hayashi; Ryuichi Abe; Satoki Inoue; Hiroyuki Nakase; Hitoshi Furuya
Related Documents :
16252739 - Initial injection pressure for dental local anesthesia: effects on pain and anxiety.
9563639 - Cardiovascular effects of the alpha2-adrenergic receptor agonist medetomidine in clinic...
2897809 - Synergistic interaction of alpha 1- and beta-adrenoceptor agonists on induction arrhyth...
11493499 - Isoflurane-induced protection against myocardial stunning is independent of adenosine 1...
3142969 - Effect of sevoflurane on p50 and on measurement of oxygen tension.
10871229 - The hemodynamic effects of intrathecal oxytocin in normal dogs.
7283479 - Urodynamic findings following surgery in women with urinary stress incontinence. iii. c...
3022609 - Total peripheral resistance during cardiac tamponade: adrenergic and angiotensin roles.
17949169 - Molar volume, excess enthalpy, and prigogine-defay ratio of some silicate glasses with ...
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2010-03-26
Journal Detail:
Title:  Journal of anesthesia     Volume:  24     ISSN:  1438-8359     ISO Abbreviation:  J Anesth     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-08-05     Completed Date:  2010-12-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8905667     Medline TA:  J Anesth     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  503-10     Citation Subset:  IM    
Affiliation:
Department of Anesthesiology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 623-8522, Japan. drjkawa@naramed-u.ac.jp
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adrenergic beta-Antagonists / pharmacology*
Aged
Anesthesia*
Brain / drug effects*,  physiology
Craniotomy*
Female
Hemodynamics / drug effects*
Humans
Male
Middle Aged
Morpholines / pharmacology*
Prospective Studies
Urea / analogs & derivatives*,  pharmacology
Chemical
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Morpholines; 133242-30-5/landiolol; 57-13-6/Urea

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Significance of prevention and early treatment of a postoperative twisted neck: atlantoaxial rotator...
Next Document:  Pituitary apoplexy during general anesthesia in beach chair position for shoulder joint arthroplasty...