| Effects of landiolol, a short-acting beta-1 blocker, on hemodynamic variables during emergence from anesthesia and tracheal extubation in elderly patients with and without hypertension. | |
| | |
MedLine Citation:
|
PMID: 19921354 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE: Tracheal extubation and emergence procedures induce abrupt changes in hemodynamics and humoral responses. We conducted a prospective randomized study to examine the effects of the short-acting beta-1 blocker, landiolol, on hemodynamics during emergence from anesthesia in elderly patients with and without hypertension. METHODS: Thirty-one hypertensive and 32 normotensive elderly patients were randomly divided into two groups: a control (placebo group) and a landiolol infusion group. Landiolol was dissolved in 20 ml of saline and administered as an infusion at the rate of 0.125 mg kg(-1) min(-1) for 1 min and then decreased to 0.04 mg kg(-1) min(-1) until extubation. Control patients received an equal volume of saline. Heart rate and blood pressure were recorded every minute from immediately before the administration of landiolol up to the discontinuation of landiolol, and every 5 min from the discontinuation of landiolol to 30 min after termination of the infusion. RESULTS: Systolic blood pressure in the control group patients with hypertension increased during anesthesia emergence and tracheal extubation, as did the heart rate. Landiolol infusion in the elderly patients with hypertension partially prevented the increase in systolic blood pressure and completely prevented the increase in heart rate associated with emergence from anesthesia. Landiolol infusion in the elderly patients without hypertension brought about a decrease in heart rate during emergence and tracheal extubation. CONCLUSION: This study indicates that the use of a landiolol infusion for preventing hemodynamic instability in elderly patients during the emergence period would be dependent on the presence or absence of hypertension in these patients. |
| | |
Authors:
|
Masumi Miyazaki; Yuji Kadoi; Shigeru Saito |
Related Documents
:
|
18160154 - Diastolic heart failure in the elderly: underlying mechanisms and clinical relevance. 2165824 - Effects of isoproterenol in panic disorder patients after antidepressant treatment. 3732094 - Diuretic therapy in congestive heart failure for the elderly patient. 6355394 - Predicting treatment response to relaxation therapy for essential hypertension. 20525554 - Evaluation of surgical procedure selection based on intraoperative free portal pressure... 19808574 - Impact of mild hypertension on left atrial size and function. |
Publication Detail:
|
Type: Journal Article; Randomized Controlled Trial Date: 2009-11-18 |
Journal Detail:
|
Title: Journal of anesthesia Volume: 23 ISSN: 1438-8359 ISO Abbreviation: J Anesth Publication Date: 2009 |
Date Detail:
|
Created Date: 2009-11-20 Completed Date: 2010-01-26 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8905667 Medline TA: J Anesth Country: Japan |
Other Details:
|
Languages: eng Pagination: 483-8 Citation Subset: IM |
Affiliation:
|
Department of Anesthesia, Tomioka General Hospital, Tomioka, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adrenergic beta-Antagonists
/
pharmacology*,
therapeutic use Aged Anesthesia Recovery Period* Blood Pressure / drug effects Electroencephalography Female Gynecologic Surgical Procedures Heart Rate / drug effects Hemodynamics / drug effects* Humans Hypertension / drug therapy*, physiopathology* Intubation, Intratracheal* Male Monitoring, Intraoperative Morpholines / pharmacology*, therapeutic use Orthopedic Procedures Urea / analogs & derivatives*, pharmacology, therapeutic use |
| Chemical | |
Reg. No./Substance:
|
0/Adrenergic beta-Antagonists; 0/Morpholines; 133242-30-5/landiolol; 57-13-6/Urea |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Jugular bulb desaturation during off-pump coronary artery bypass surgery.
Next Document: Effect of different anesthetic agents on oculocardiac reflex in pediatric strabismus surgery.