| Effects of lactose intake on lactose digestion and colonic fermentation in preterm infants. | |
| | |
MedLine Citation:
|
PMID: 9738725 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The purpose of this study was to determine whether doubling the lactose concentration in formula for preterm infants lowers the fraction of lactose digested and/or increases the fraction of lactose fermented. Six preterm infants, 31 to 36 weeks' postconceptional age, were fed a standard preterm formula (carbohydrate is 50% lactose and 50% glucose polymer)(SC) and/or the same volume of formula modified to contain lactose as the sole carbohydrate (LAC). Relative lactose digestion during the LAC formula feeding compared with SC formula feeding was measured by using a stable isotope approach for quantifying the fractional contribution of formula lactose to plasma glucose enrichment. Relative lactose digestion was 0.98 +/- 0.17 (range, 0.70 to 1.19). Fractional fermentation of lactose was estimated from breath H2 excretion (0.52 +/- 0.34 during LAC feeding and 0.23 +/- 0.22 during SC feeding, P = .11). The rate of breath H2 excretion was much higher with LAC (1.34 +/- 0.98 mL/h) than with SC (0.27 +/- 0.29, P = .029). In conclusion, doubling the lactose concentration had only modest effects on fractional lactose digestion. Increased breath H2 excretion with LAC may relate to fermentation of nonlactose sugar or to ill-defined changes in colonic physiology or motility, which could enhance colonic fermentation of malabsorbed sugar by H2-producing bacteria. |
| | |
Authors:
|
C L Kien; R E McClead; L Cordero |
Related Documents
:
|
1113235 - Correction of the malabsorption of the preterm infant with a medium-chain triglyceride ... 3381775 - Diluted formula for beginning the feeding of premature infants. 8172105 - Zinc supplementation of infant formula. 6134885 - Diet and antibody response to vaccinations in healthy infants. 22339845 - Parental involvement in neonatal pain management: an empirical and conceptual update. 10190265 - Infantile botulism: pitfalls in electrodiagnosis. |
Publication Detail:
|
Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: The Journal of pediatrics Volume: 133 ISSN: 0022-3476 ISO Abbreviation: J. Pediatr. Publication Date: 1998 Sep |
Date Detail:
|
Created Date: 1998-10-01 Completed Date: 1998-10-01 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 401-5 Citation Subset: AIM; IM |
Affiliation:
|
Department of Pediatrics, The Ohio State University, and The Ohio State University Hospitals, Columbus, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Bacteria
/
metabolism Blood Glucose / analysis Carbon Dioxide / metabolism Carbon Isotopes Colon / metabolism*, microbiology, physiology Cross-Over Studies Dietary Carbohydrates / administration & dosage*, metabolism Double-Blind Method Fermentation Gastrointestinal Motility Glucose / administration & dosage, metabolism Humans Hydrogen / metabolism Hydrolysis Infant Food* Infant, Newborn Infant, Premature / metabolism* Intestinal Absorption Lactose / administration & dosage*, metabolism Respiration |
| Grant Support | |
ID/Acronym/Agency:
|
HD 19773/HD/NICHD NIH HHS; M01 RR00034/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Blood Glucose; 0/Carbon Isotopes; 0/Dietary Carbohydrates; 124-38-9/Carbon Dioxide; 1333-74-0/Hydrogen; 50-99-7/Glucose; 63-42-3/Lactose |
| Comments/Corrections | |
Comment In:
|
J Pediatr. 2001 Jan;138(1):148-9
[PMID:
11148537
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Side effects of 2 different dexamethasone courses for preterm infants at risk of chronic lung diseas...
Next Document: An optimality score for the neurologic examination of the term newborn.