| Effects of Lactobacillus fermented soymilk and soy yogurt on hepatic lipid accumulation in rats fed a cholesterol-free diet. | |
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MedLine Citation:
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PMID: 19584552 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We examined the effects of lactic acid fermented soymilk, in which part of the soymilk was replaced with okara (soy yogurt), on plasma and hepatic lipid profiles in rats fed a cholesterol-free diet. Additionally, we investigated the effects of soy yogurt on hepatic gene expression in rats using DNA microarray analysis. Male Sprague-Dawley rats aged 5 weeks (n=5/group) were fed a control diet (AIN-93) or a test diet in which 20% of the diet was replaced by soy yogurt for 7 weeks. Soy yogurt consumption did not affect body weight or adipose tissue weight as compared with control diet. In the soy yogurt group, the liver weight and hepatic triglyceride content were significantly lower than the control group, and the level of plasma cholesterol was also lower. Furthermore, DNA microarray analysis indicated that soy yogurt ingestion down-regulated the expression of the SREBP-1 gene and enzymes related to lipogenesis in the rat liver, while expression of beta-oxidation-related genes was up-regulated. These results suggest that soy yogurt is beneficial in preventing hepatic lipid accumulation in rats. |
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Authors:
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Ryoko Kitawaki; Yuko Nishimura; Naohiro Takagi; Mitsuhiro Iwasaki; Kimiko Tsuzuki; Mitsuru Fukuda |
Publication Detail:
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Type: Journal Article Date: 2009-07-07 |
Journal Detail:
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Title: Bioscience, biotechnology, and biochemistry Volume: 73 ISSN: 1347-6947 ISO Abbreviation: Biosci. Biotechnol. Biochem. Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-07-24 Completed Date: 2009-11-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9205717 Medline TA: Biosci Biotechnol Biochem Country: Japan |
Other Details:
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Languages: eng Pagination: 1484-8 Citation Subset: IM |
Affiliation:
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Department of Food Science and Nutrition, School of Human Environmental Sciences, Mukogawa Women's University, Nishinomiya, Hyogo, Japan. senjuoka@mukogawa-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bile Acids and Salts / metabolism Body Weight / drug effects Cholesterol, Dietary Diet* Eating / drug effects Feces Fermentation* Gene Expression Regulation / drug effects Lactic Acid / metabolism Lactobacillus / metabolism* Lipid Metabolism / drug effects* Lipids / blood Liver / anatomy & histology, drug effects, metabolism* Male Oligonucleotide Array Sequence Analysis Organ Size / drug effects Rats Rats, Sprague-Dawley Soy Milk / metabolism, pharmacology* Yogurt / microbiology* |
| Chemical | |
Reg. No./Substance:
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0/Bile Acids and Salts; 0/Cholesterol, Dietary; 0/Lipids; 50-21-5/Lactic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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