| Effects of lactide monomer on the hydrolytic degradation of poly(lactide-co-glycolide) 85L/15G. | |
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MedLine Citation:
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PMID: 21783137 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The hydrolytic degradation of oriented poly(L-lactide-co-glycolide) 85L/15G (PLGA 85/15) sample materials with various amounts of lactide monomer was monitored in vitro at 37 °C. The materials were manufactured from medical grade PLGA 85/15 by a two-step melt extrusion-die drawing process. Results showed that the hydrolytic degradation rate depended highly on the lactide monomer content, which in turn influenced the retention of mechanical properties, mass loss, crystallinity, and dimensional stability. Even small quantities of lactide monomer (0.05-0.20 wt%) affected especially the retention of mechanical properties, which started to decline rapidly upon the inherent viscosity reaching 0.6-0.8 dl/g due to hydrolytic degradation. Based on our hydrolytic degradation data, we constructed a simplified mathematical model of degradation-related strength retention and recommend it as a functional quality control tool for melt-processed biodegradable medical devices manufactured from poly(L-lactide-co-glycolide) 85L/15G. |
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Authors:
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K Paakinaho; H Heino; J Väisänen; P Törmälä; M Kellomäki |
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Publication Detail:
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Type: Journal Article Date: 2011-04-29 |
Journal Detail:
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Title: Journal of the mechanical behavior of biomedical materials Volume: 4 ISSN: 1878-0180 ISO Abbreviation: J Mech Behav Biomed Mater Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-07-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101322406 Medline TA: J Mech Behav Biomed Mater Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1283-90 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Biomedical Engineering, Tampere University of Technology, Hermiankatu 12, P.O. Box 692, FI-33101 Tampere, Finland. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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