Document Detail

Effects of labetalol on systemic and pulmonary haemodynamics at rest and during exercise in hypertensive patients.
MedLine Citation:
PMID:  282068     Owner:  NLM     Status:  MEDLINE    
1. Labetalol was administered to 18 hypertensive patients for an average duration of 2.44 weeks, with an average final daily dose of 1.65 g. 2. Labetalol decreased resting heart rate by 16% and maximal exercise heart rate by 21%; the phenylephrine-induced rise of systolic brachial artery pressure was reduced by 36%. 3. During labetalol brachial artery pressure was lowered by 29/15 mmHg in the recumbent position, by 41/23 mmHg at rest sitting, and by 53/23 mmHg at maximal exercise; total peripheral resistance was not significantly affected at rest recumbent, but was reduced at sitting and at exercise; cardiac output decreased in all conditions. 4. Labetalol reduced mean pulmonary artery and capillary wedge pressures only in the sitting position. Pulmonary vascular resistance remained unchanged. 5. The drug produced significant decreases of plasma renin activity and of plasma aldosterone concentration.
R Fagard; A Amery; T Reybrouck; P Lijnen; L Billiet
Related Documents :
1939868 - The pulmonary circulation in acute lung injury: a review of some recent advances.
8811618 - Comparison of circulatory effects between arginine vasopressin (avp) and dopamine in co...
1926148 - Effects of indomethacin in utero on the pulmonary vasculature of the newborn lambs.
3300118 - Volume substitution and treatment with prostaglandin e1 in a porcine model of endotoxae...
15703898 - Prone position improves mechanics and alveolar ventilation in acute respiratory distres...
2885358 - Intrathecally administered angiotensin ii increases sympathetic activity in the rat.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical science and molecular medicine. Supplement     Volume:  4     ISSN:  0144-4107     ISO Abbreviation:  Clin Sci Mol Med Suppl     Publication Date:  1978 Dec 
Date Detail:
Created Date:  1979-03-24     Completed Date:  1979-03-24     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7907311     Medline TA:  Clin Sci Mol Med Suppl     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  279s-281s     Citation Subset:  IM; S    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aldosterone / blood
Ethanolamines / therapeutic use*
Hemodynamics / drug effects*
Hypertension / drug therapy*,  physiopathology
Labetalol / pharmacology,  therapeutic use*
Middle Aged
Physical Exertion
Pulmonary Circulation / drug effects
Renin / blood
Reg. No./Substance:
0/Ethanolamines; 36894-69-6/Labetalol; 52-39-1/Aldosterone; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Pharmacokinetics of intravenous and oral pindolol in hypertensive patients with chronic renal failur...
Next Document:  Effect of selective and non-selective beta-adrenoreceptor blockade on calf blood flow in hypertensiv...