Document Detail


Effects of labetalol on systemic and pulmonary haemodynamics at rest and during exercise in hypertensive patients.
MedLine Citation:
PMID:  282068     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. Labetalol was administered to 18 hypertensive patients for an average duration of 2.44 weeks, with an average final daily dose of 1.65 g. 2. Labetalol decreased resting heart rate by 16% and maximal exercise heart rate by 21%; the phenylephrine-induced rise of systolic brachial artery pressure was reduced by 36%. 3. During labetalol brachial artery pressure was lowered by 29/15 mmHg in the recumbent position, by 41/23 mmHg at rest sitting, and by 53/23 mmHg at maximal exercise; total peripheral resistance was not significantly affected at rest recumbent, but was reduced at sitting and at exercise; cardiac output decreased in all conditions. 4. Labetalol reduced mean pulmonary artery and capillary wedge pressures only in the sitting position. Pulmonary vascular resistance remained unchanged. 5. The drug produced significant decreases of plasma renin activity and of plasma aldosterone concentration.
Authors:
R Fagard; A Amery; T Reybrouck; P Lijnen; L Billiet
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical science and molecular medicine. Supplement     Volume:  4     ISSN:  0144-4107     ISO Abbreviation:  Clin Sci Mol Med Suppl     Publication Date:  1978 Dec 
Date Detail:
Created Date:  1979-03-24     Completed Date:  1979-03-24     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7907311     Medline TA:  Clin Sci Mol Med Suppl     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  279s-281s     Citation Subset:  IM; S    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aldosterone / blood
Ethanolamines / therapeutic use*
Female
Hemodynamics / drug effects*
Humans
Hypertension / drug therapy*,  physiopathology
Labetalol / pharmacology,  therapeutic use*
Male
Middle Aged
Physical Exertion
Posture
Pulmonary Circulation / drug effects
Renin / blood
Chemical
Reg. No./Substance:
0/Ethanolamines; 36894-69-6/Labetalol; 52-39-1/Aldosterone; EC 3.4.23.15/Renin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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