| Effects of l-menthol and dl-camphor on the penetration and hydrolysis of methyl salicylate in hairless mouse skin. | |
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MedLine Citation:
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PMID: 1812275 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Plasters containing methyl salicylate with and without l-menthol and dl-camphor were prepared and topically applied on hairless mouse skin to investigate the effects of l-menthol and dl-camphor on the skin penetration and hydrolysis of methyl salicylate in the skin. The in vitro hydrolysis of methyl salicylate was also investigated using the skin homogenate. It was found that l-menthol with dl-camphor enhanced the skin penetration of methyl salicylate, and they inhibited both the in vivo and in vitro hydrolysis of methyl salicylate to salicylic acid. |
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Authors:
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T Yano; T Kanetake; M Saita; K Noda |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of pharmacobio-dynamics Volume: 14 ISSN: 0386-846X ISO Abbreviation: J. Pharmacobio-dyn. Publication Date: 1991 Dec |
Date Detail:
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Created Date: 1992-06-10 Completed Date: 1992-06-10 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7901854 Medline TA: J Pharmacobiodyn Country: JAPAN |
Other Details:
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Languages: eng Pagination: 663-9 Citation Subset: IM |
Affiliation:
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Research Laboratories, Hisamitsu Pharmaceutical Co., Inc., Saga, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Topical Animals Camphor / pharmacology* Chromatography, Gas Female Hydrolysis Menthol / pharmacology* Mice Mice, Hairless Salicylates / pharmacokinetics* Skin / drug effects, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Salicylates; 119-36-8/methyl salicylate; 1490-04-6/Menthol; 76-22-2/Camphor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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