Document Detail

Effects of l-menthol and dl-camphor on the penetration and hydrolysis of methyl salicylate in hairless mouse skin.
MedLine Citation:
PMID:  1812275     Owner:  NLM     Status:  MEDLINE    
Plasters containing methyl salicylate with and without l-menthol and dl-camphor were prepared and topically applied on hairless mouse skin to investigate the effects of l-menthol and dl-camphor on the skin penetration and hydrolysis of methyl salicylate in the skin. The in vitro hydrolysis of methyl salicylate was also investigated using the skin homogenate. It was found that l-menthol with dl-camphor enhanced the skin penetration of methyl salicylate, and they inhibited both the in vivo and in vitro hydrolysis of methyl salicylate to salicylic acid.
T Yano; T Kanetake; M Saita; K Noda
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pharmacobio-dynamics     Volume:  14     ISSN:  0386-846X     ISO Abbreviation:  J. Pharmacobio-dyn.     Publication Date:  1991 Dec 
Date Detail:
Created Date:  1992-06-10     Completed Date:  1992-06-10     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7901854     Medline TA:  J Pharmacobiodyn     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  663-9     Citation Subset:  IM    
Research Laboratories, Hisamitsu Pharmaceutical Co., Inc., Saga, Japan.
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MeSH Terms
Administration, Topical
Camphor / pharmacology*
Chromatography, Gas
Menthol / pharmacology*
Mice, Hairless
Salicylates / pharmacokinetics*
Skin / drug effects,  metabolism*
Reg. No./Substance:
0/Salicylates; 119-36-8/methyl salicylate; 1490-04-6/Menthol; 76-22-2/Camphor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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