Document Detail

Effects of kinin blockade on the blood pressure of salt-loaded pregnant rats.
MedLine Citation:
PMID:  7721438     Owner:  NLM     Status:  MEDLINE    
We evaluated whether chronic inhibition of bradykinin B2 receptors by the long-acting antagonist D-Arg, [Hyp3, Thi5,D-Tic7,Oic8]-bradykinin (Hoe 140) affects blood pressure of salt-loaded pregnant rats. Pairs of rats fed a high sodium diet (0.84 mmol sodium per gram chow) were mated at 14 weeks of age. Infusion of vehicle or Hoe 140 (300 nmol/d per kilogram body weight) was performed throughout each dam's pregnancy by use of an Alzet osmotic pump implanted in the abdominal cavity. In both groups, no significant change in systolic pressure (tail-cuff plethysmography) or renal blood flow (Doppler flow-meter) was observed from that in the unmated state to that at midterm pregnancy. In the control group, systolic pressure decreased at the 21st day of pregnancy (from 126 +/- 2 to 97 +/- 2 mm Hg, P < .01), and renal blood flow increased (from 6.1 +/- 0.1 to 7.5 +/- 0.2 kHz, P < .01). These changes were nullified by the administration of Hoe 140 (systolic pressure changing from 124 +/- 2 to 118 +/- 4 mm Hg, P = NS; renal blood flow changing from 6.3 +/- 0.2 to 6.2 +/- 0.1 kHz, P = NS). In the group given Hoe 140, placental weight was greater (0.50 +/- 0.01 versus 0.43 +/- 0.01 g in controls, P < .01) and the fetal/placental weight ratio was reduced (4.53 +/- 0.09 versus 5.31 +/- 0.17 in controls, P < .01).(ABSTRACT TRUNCATED AT 250 WORDS)
P Madeddu; P P Parpaglia; M P Demontis; M V Varoni; M C Fattaccio; V Anania; N Glorioso
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hypertension     Volume:  25     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:  1995 Apr 
Date Detail:
Created Date:  1995-05-25     Completed Date:  1995-05-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  823-7     Citation Subset:  IM    
Clinica Medica, University of Sassari, Italy.
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MeSH Terms
Animals, Newborn
Blood Pressure* / drug effects
Bradykinin / analogs & derivatives,  pharmacology
Diet, Sodium-Restricted*
Pregnancy, Animal / physiology*
Rats, Wistar
Receptors, Bradykinin / antagonists & inhibitors*
Reference Values
Renal Circulation / drug effects
Survival Analysis
Reg. No./Substance:
0/Receptors, Bradykinin; 130308-48-4/icatibant; 58-82-2/Bradykinin
Erratum In:
Hypertension 1995 Jun;25(6):1351

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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