Document Detail

Effects of ketamine, propofol, or thiopental administration on intraocular pressure and qualities of induction of and recovery from anesthesia in horses.
MedLine Citation:
PMID:  23879844     Owner:  NLM     Status:  In-Data-Review    
Objective-To assess the effects of ketamine hydrochloride, propofol, or compounded thiopental sodium administration on intraocular pressure (IOP) and qualities of induction of and recovery from anesthesia in horses. Animals-6 healthy adult horses. Procedures-Horses were sedated with xylazine hydrochloride (0.5 mg/kg), and anesthesia was induced with guaifenesin followed by ketamine (2 mg/kg), propofol (3 mg/kg), or thiopental (4 mg/kg) in a crossover study with ≥ 1 week between treatments. For each horse, IOP in the right eye was measured with a handheld applanation tonometer before and after xylazine administration, at the time of recumbency, and every 3 minutes after induction of anesthesia until spontaneous movement was observed. Cardiorespiratory responses and venous blood measurements were recorded during anesthesia. Induction of and recovery from anesthesia were subjectively evaluated by investigators who were unaware of the anesthetic treatment of each horse. Data were analyzed via a repeated-measures ANOVA with Holm-Ŝidák post hoc comparisons. Results-Compared with findings after xylazine administration (mean ± SD, 17 ± 3 mm Hg), thiopental decreased IOP by 4 ± 23%, whereas propofol and ketamine increased IOP by 8 ± 11% and 37 ± 16%, respectively. Compared with the effects of ketamine, propofol and thiopental resulted in significantly lower IOP at the time of recumbency and higher heart rates at 3 minutes after induction of anesthesia. No other significant differences among treatments were found. Conclusions and Clinical Relevance-These findings support the use of thiopental or propofol in preference to ketamine for horses in which increases in IOP should be minimized.
Tatiana H Ferreira; Robert J Brosnan; Yael Shilo-Benjamini; Stephanie B Moore; Steven R Hollingsworth
Related Documents :
19867464 - Further observations on certain features of experimental syphilis and yaws in the rabbit.
8484614 - Exogenous surfactant rapidly increases pao2 in mature rabbits with lungs that contain l...
21299084 - Accuracy of transcutaneous bilirubinometry compare to total serum bilirubin measurement.
24338124 - Reconsidering the switch from low-molecular-weight heparin to unfractionated heparin du...
8322244 - Effect of azelastine on sulphur dioxide induced impairment of ciliary motility in airwa...
11602544 - Effects of intravenous dofetilide on induction of atrioventricular re-entrant tachycardia.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of veterinary research     Volume:  74     ISSN:  1943-5681     ISO Abbreviation:  Am. J. Vet. Res.     Publication Date:  2013 Aug 
Date Detail:
Created Date:  2013-07-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375011     Medline TA:  Am J Vet Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1070-7     Citation Subset:  IM    
Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, CA 95616.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Isolation rates of Campylobacter fetus subsp venerealis from bovine preputial samples via passive fi...
Next Document:  Effects of subtherapeutic concentrations of antimicrobials on gene acquisition events in Yersinia, P...