Document Detail

Effects of kappa opioid agonists on the discriminative stimulus effects of cocaine in rhesus monkeys.
MedLine Citation:
PMID:  10609965     Owner:  NLM     Status:  MEDLINE    
This study examined the effects of the kappa opioid agonists U50,488 and ethylketocyclazocine (EKC) on cocaine discrimination in rhesus monkeys trained to discriminate cocaine (0.4 mg/kg) from saline. Administration of U50,488 and EKC alone produced primarily saline-appropriate responding. Kappa agonist pretreatments produced variable effects on cocaine discrimination across monkeys, attenuating the discriminative stimulus effects of cocaine in some monkeys, but either having no effect on cocaine discrimination or enhancing the discriminative stimulus effects of cocaine in other monkeys. The effects of kappa agonists on cocaine discrimination were reversed by pretreatment with the opioid antagonist naloxone (1.0 mg/kg). These results indicate that kappa agonists do not consistently block the discriminative stimulus effects of cocaine in rhesus monkeys.
S S Negus; N K Mello
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Experimental and clinical psychopharmacology     Volume:  7     ISSN:  1064-1297     ISO Abbreviation:  Exp Clin Psychopharmacol     Publication Date:  1999 Nov 
Date Detail:
Created Date:  2000-01-28     Completed Date:  2000-01-28     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9419066     Medline TA:  Exp Clin Psychopharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  307-17     Citation Subset:  IM    
McLean Hospital--Harvard Medical School, Belmont, Massachusetts 02178, USA.
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MeSH Terms
3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer / pharmacology
Analgesics, Opioid / pharmacology
Cocaine / pharmacology*
Discrimination (Psychology) / drug effects*
Discrimination Learning / drug effects
Dopamine Antagonists / pharmacology
Dopamine Uptake Inhibitors / pharmacology*
Dose-Response Relationship, Drug
Ethylketocyclazocine / pharmacology
Macaca mulatta
Naloxone / pharmacology
Narcotic Antagonists / pharmacology
Receptors, Dopamine D2 / antagonists & inhibitors
Receptors, Opioid, kappa / agonists*
Salicylamides / pharmacology
Grant Support
Reg. No./Substance:
0/Analgesics, Opioid; 0/Dopamine Antagonists; 0/Dopamine Uptake Inhibitors; 0/Narcotic Antagonists; 0/Receptors, Dopamine D2; 0/Receptors, Opioid, kappa; 0/Salicylamides; 465-65-6/Naloxone; 50-36-2/Cocaine; 58640-84-9/Ethylketocyclazocine; 67198-13-4/3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; 84226-12-0/eticlopride

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