| Effects of kainic acid, quisqualic acid, and their antagonist, pCB-PzDA, on rat electrocorticograms and monoamine metabolite levels in rat striatum. | |
| | |
MedLine Citation:
|
PMID: 7513829 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The action of kainic acid (KA), quisqualic acid (QA), and 1-(4-chlorobenzoyl)-piperazine-2,3-dicarboxylic acid (pCB-PzDA) was investigated in the central nervous system of male Sprague Dawley rats. Intracerebroventricularly injected KA and QA (100 nmol) induced spike discharges, and pCB-PzDA (100 nmol) suppressed electrocorticograms for one hour. pCB-PzDA enhanced the KA-induced spike discharges and inhibited those induced by QA. 2,3-Di-hydroxyphenylacetic acid(DOPAC) and homovanillic acid (HVA) levels were increased transiently by 10 nmol and continuously by 100 nmol of KA. KA dose-dependently increased 5-hydroxyindoleacetic acid (5-HIAA) levels 2 hours after administration. While 10 nmol of QA slightly increased the HVA level, 100 nmol of QA significantly increased DOPAC, HVA, and 5-HIAA levels. DOPAC and HVA levels were increased by 100 nmol of pCB-PzDA, although this agent inhibited KA-induced increases in DOPAC, HVA, and 5-HIAA levels. On the other hand, while pCB-PzDA first inhibited QA-induced increases in DOPAC, HVA and 5-HIAA levels for one hour, DOPAC and HVA levels thereafter increased additively. These findings suggest that pCB-PzDA may act not only as a NMDA antagonist, but that it may also act directly on dopaminergic neurons. |
| | |
Authors:
|
H Kabuto; I Yokoi; S MoonSuk; M Yamamoto; A Mori |
Related Documents
:
|
9070639 - Differential effects of kainic acid on dopamine and serotonin metabolism in ventral and... 4010149 - Origin of positive transepithelial potential difference in early distal segments of rat... 1710099 - Altered serotonin activity in anorexia nervosa after long-term weight restoration. does... 2260859 - Stiff-man syndrome: a gabaergic autoimmune disorder with autoantigenic heterogeneity. 19453159 - (1)h nmr based metabonomics of human amniotic fluid for the metabolic characterization ... 1173549 - Palmitic acid and lecithin measurements in amniotic fluid. 894139 - Lipids of the anal sac secretions of the red fox, vulpes vulpes and of the lion, panthe... 18262699 - Usnic acid controls the acidity tolerance of lichens. 8738769 - Displacement of valproic acid and carbamazepine from protein binding in normal and urem... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Neurochemical research Volume: 19 ISSN: 0364-3190 ISO Abbreviation: Neurochem. Res. Publication Date: 1994 Mar |
Date Detail:
|
Created Date: 1994-06-06 Completed Date: 1994-06-06 Revised Date: 2003-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 7613461 Medline TA: Neurochem Res Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 267-74 Citation Subset: IM |
Affiliation:
|
Department of Neuroscience, Okayama University Medical School, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
3,4-Dihydroxyphenylacetic Acid
/
metabolism Animals Biogenic Monoamines / metabolism* Brain / drug effects, metabolism* Cerebral Cortex / drug effects, physiology* Chromatography, High Pressure Liquid Corpus Striatum / drug effects, metabolism, physiology* Electroencephalography / drug effects* Homovanillic Acid / metabolism Hydroxyindoleacetic Acid / metabolism Kainic Acid / antagonists & inhibitors, pharmacology* Kinetics Male Piperazines / pharmacology* Quisqualic Acid / antagonists & inhibitors, pharmacology* Rats Rats, Sprague-Dawley Time Factors |
| Chemical | |
Reg. No./Substance:
|
0/Biogenic Monoamines; 0/Piperazines; 102-32-9/3,4-Dihydroxyphenylacetic Acid; 306-08-1/Homovanillic Acid; 487-79-6/Kainic Acid; 52809-07-1/Quisqualic Acid; 54-16-0/Hydroxyindoleacetic Acid; 94856-91-4/1-(4-chlorobenzoyl)piperazine-2,3-dicarboxylic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Formation and persistence of DNA adducts in pouch skin fibroblasts and liver tissue of rats exposed ...
Next Document: Palliative treatment of pancreatic carcinoma. Comparison between 2 successive observation periods