| Effects of kainate during glutamine synthetase induction in chick embryo retina. | |
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MedLine Citation:
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PMID: 6120796 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This report concerns the effect of kainate on induction of glutamine synthetase in chick embryo retina. This enzyme can be prematurely induced in such retinas at 12 days of development by cortisol. Induction is 50-70% inhibited if 2.4 mM L-glutamate is added to the medium with cortisol for the 24-h induction period. Addition of kainate, an analogue of glutamate, enhances cortisol induction of glutamine synthetase by a factor of 2 under similar conditions. Kainate or L-glutamate treatment for 5 min (followed by incubation with cortisol for 24 h) also sometimes enhances retinal glutamine synthetase compared with untreated controls. |
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Authors:
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L Reif-Lehrer |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Current eye research Volume: 1 ISSN: 0271-3683 ISO Abbreviation: Curr. Eye Res. Publication Date: 1981 |
Date Detail:
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Created Date: 1982-05-27 Completed Date: 1982-05-27 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8104312 Medline TA: Curr Eye Res Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 445-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chick Embryo Glutamate-Ammonia Ligase / biosynthesis* Glutamates / pharmacology Hydrocortisone / pharmacology Kainic Acid / pharmacology* Pyrrolidines / pharmacology* Retina / drug effects*, enzymology Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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5R01EY02171/EY/NEI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Glutamates; 0/Pyrrolidines; 487-79-6/Kainic Acid; 50-23-7/Hydrocortisone; EC 6.3.1.2/Glutamate-Ammonia Ligase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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