| Effects of isosorbide dinitrate on pancreatic exocrine secretion in the dog. | |
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MedLine Citation:
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PMID: 4004420 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of isosorbide dinitrate (ISDN) on pancreatic exocrine secretion were investigated after intravenous administration in the whole animal and after close-arterial administration on the isolated and blood-perfused dog pancreas preparations. ISDN (10-100 micrograms/kg), injected into the femoral vein, caused a dose-dependent increase in flow rate of pancreatic juice and in protein concentration of the pancreatic juice. Close-arterial injections of ISDN (100-1000 micrograms) produced a dose-dependent increase in perfusion blood flow, flow rate of pancreatic juice and protein concentration of the pancreatic juice without affecting its bicarbonate concentration. These vascular and secretory effects were not modified by pretreatment with atropine. From these data, it is suggested that ISDN induces pancreatic enzyme secretion by acting directly on the acinar cells of the pancreas. |
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Authors:
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F Yamagishi; K Haruta; N Homma; K Iwatsuki; S Chiba |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Archives internationales de pharmacodynamie et de thérapie Volume: 273 ISSN: 0003-9780 ISO Abbreviation: Arch Int Pharmacodyn Ther Publication Date: 1985 Feb |
Date Detail:
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Created Date: 1985-07-12 Completed Date: 1985-07-12 Revised Date: 2012-01-12 |
Medline Journal Info:
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Nlm Unique ID: 0405353 Medline TA: Arch Int Pharmacodyn Ther Country: BELGIUM |
Other Details:
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Languages: eng Pagination: 306-13 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cholecystokinin / pharmacology Dogs Female Injections, Intra-Arterial Injections, Intravenous Isosorbide Dinitrate / pharmacology* Male Pancreas / blood supply, drug effects*, secretion Pancreatic Juice / secretion Regional Blood Flow / drug effects Secretin / pharmacology |
| Chemical | |
Reg. No./Substance:
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1393-25-5/Secretin; 87-33-2/Isosorbide Dinitrate; 9011-97-6/Cholecystokinin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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