Document Detail

Effects of isoprenaline on the responses of slowly adapting pulmonary stretch receptors to reduced lung compliance and to administered histamine.
MedLine Citation:
PMID:  8084535     Owner:  NLM     Status:  MEDLINE    
To define the difference between the responses of slowly adapting pulmonary stretch receptors (SARs) to reduced dynamic lung compliance (Cdyn) and to administered histamine, experiments were performed in open-chest, artificially ventilated, bilaterally vagotomized rabbits with positive end-expiratory pressure (PEEP). Both stimuli caused an increase in tracheal pressure and produced augmentation of SAR activities during inflation and deflation. Isoprenaline treatment that blocked the responses of SARs and PT to histamine had no effect on those to reduced Cdyn. The results suggest that the response characteristics of SARs provoked by histamine administration do not involve the contribution of decreased Cdyn.
S Matsumoto; T Shimizu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neuroscience letters     Volume:  172     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  1994 May 
Date Detail:
Created Date:  1994-10-11     Completed Date:  1994-10-11     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  47-50     Citation Subset:  IM    
Department of Physiology, Fukushima Medical College, Japan.
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MeSH Terms
Histamine / pharmacology*
Isoproterenol / pharmacology*
Lung Compliance / drug effects*
Pulmonary Stretch Receptors / drug effects*
Respiration, Artificial
Reg. No./Substance:
51-45-6/Histamine; 7683-59-2/Isoproterenol

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