Document Detail

Effects of isometric exercise on subfoveal choroidal blood flow in smokers and nonsmokers.
MedLine Citation:
PMID:  14578409     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Little is known about potential effects of smoking on ocular blood flow regulation. In the present study, the hypothesis was that choroidal blood flow (CBF) changes during an increase in ocular perfusion pressure induced by isometric exercise are altered in chronic smokers. METHODS: The study was performed in 24 (12 smokers and 12 nonsmokers) healthy male volunteers in an observer-masked, two-cohort study design. The difference in CBF regulation between smokers and nonsmokers was tested during isometric exercise over a period of 6 minutes. CBF was assessed with laser Doppler flowery (LDF), and ocular perfusion pressure (OPP) was calculated from mean arterial pressure (MAP) and intraocular pressure (IOP). RESULTS: Six minutes of isometric exercise induced a significant increase in MAP, pulse rate (PR), OPP, and CBF in smokers and nonsmokers (each P<0.001). The increase in CBF was significantly higher in the smoking group (P<0.001) than in the healthy control group, whereas a comparable increase in MAP (P=0.18), PR (P=0.18), and OPP (P=0.43) occurred in smokers and nonsmokers. IOP remained unchanged during isometric exercise in both groups. Moreover, in smokers, CBF started to increase at OPPs more than 49% above baseline, whereas CBF in nonsmokers remained stable until an increase in OPP of 74% over baseline. This difference between the two groups was significant (P<0.001). CONCLUSIONS: These data indicate abnormal CBF regulation in chronic smokers compared with age-matched nonsmoking subjects during isometric exercise. The pathways responsible for this abnormal blood flow response remain to be elucidated.
Barbara Wimpissinger; Hemma Resch; Fatmire Berisha; Günther Weigert; Kaija Polak; Leopold Schmetterer
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Investigative ophthalmology & visual science     Volume:  44     ISSN:  0146-0404     ISO Abbreviation:  Invest. Ophthalmol. Vis. Sci.     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-10-27     Completed Date:  2003-11-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7703701     Medline TA:  Invest Ophthalmol Vis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  4859-63     Citation Subset:  IM    
Department of Clinical Pharmacology, Vienna University, Vienna, Austria.
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MeSH Terms
Blood Flow Velocity / physiology
Blood Pressure / physiology
Choroid / blood supply*
Cohort Studies
Exercise / physiology*
Fovea Centralis
Heart Rate / physiology
Intraocular Pressure / physiology
Laser-Doppler Flowmetry
Regional Blood Flow / physiology
Smoking / physiopathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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