Document Detail

Effects of isometric exercise and heart rate on left ventricular filling pattern assessed by pulsed Doppler echocardiography.
MedLine Citation:
PMID:  2809500     Owner:  NLM     Status:  MEDLINE    
Left ventricular filling pattern was assessed by pulsed Doppler echocardiography at rest and during handgrip exercise in 33 healthy middle-aged subjects. The peak mitral flow-velocities during the early rapid filling phase (E) and during late (atrial) filling (A) were measured and the ratio of these peak flow-velocities (E:A ratio) was calculated. The E:A ratio was inversely related to age (r = -0.50), heart rate (r = -0.47) and septal thickness (r = -0.36) at rest. Exercise caused a significant (P less than 0.001) decrease in E:A ratio as a result of an increase in the peak A velocity. No significant change in the peak E velocity was observed during exercise. The exercise E:A ratio was related to heart rate (r = -0.53), but not to resting E:A ratio or age, since the decrease in E:A ratio tended to be less in the older subjects. Our study shows that isometric exercise augments the relative contribution of atrial contraction of left ventricular filling and this increase may 'mask' minor changes in resting transmitral flow pattern associated with, e.g. ageing. Secondly, in addition to age, heart rate must be taken into account when studying populations with different heart-rate levels or interventions associated with simultaneous heart rate changes.
K E Airaksinen; M J Ikäheimo; H V Huikuri; M J Koistinen; M Linnaluoto; J T Takkunen
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of internal medicine     Volume:  226     ISSN:  0954-6820     ISO Abbreviation:  J. Intern. Med.     Publication Date:  1989 Oct 
Date Detail:
Created Date:  1989-11-30     Completed Date:  1989-11-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8904841     Medline TA:  J Intern Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  245-9     Citation Subset:  IM    
Department of Medicine, Oulu University Central Hospital, Finland.
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MeSH Terms
Echocardiography, Doppler
Heart Rate*
Middle Aged
Myocardial Contraction*

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