Document Detail

Effects of isometric exercise on the end-diastolic pressure, volumes, and function of the left ventricle in man.
MedLine Citation:
PMID:  1260987     Owner:  NLM     Status:  MEDLINE    
Changes induced in left ventricular (LV) hemodynamics by isometric exercise were analyzed in 43 patients: 30 with coronary heart disease (CAD), four with noncoronary heart disease, nine normal. Volumes were angiographically determined and correlated with left ventricular end-diastolic pressure (LVEDP) both at rest and during the fifth minute of 30% sustained handgrip (HNG). All normals and eight with CAD improved LV function during HNG. LVEDP decreased or remained constant, end-diastolic volume (EDV) decreased, end-systolic volume (ESV) decreased, as ejection fraction (EF) remained constant. None of these eight CAD cases altered their regional LV contraction pattern during HNG. Twenty-five patients, 21 CAD and four nonCAD, showed diminished LV function during HNG. LVEDP increased, EDV decreased, ESV increased, as EF declined. In these 21 CAD patients, at least one major coronary vessel was narrowed 70% or more and, with but two exceptions, was not supported by adequate collaterals. In 18, new asynergic zones developed in previously normally contracting areas or pre-existing asynergic zones extended during HNG.
A P Flessas; G P Connelly; S Handa; C R Tilney; C K Kloster; R H Rimmer; J F Keefe; M D Klein; T J Ryan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Circulation     Volume:  53     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1976 May 
Date Detail:
Created Date:  1976-07-06     Completed Date:  1976-07-06     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  839-47     Citation Subset:  AIM; IM; S    
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MeSH Terms
Cardiac Output
Cardiac Volume*
Coronary Angiography
Coronary Disease / physiopathology
Heart / physiology,  physiopathology*
Heart Diseases / physiopathology*
Heart Rate
Muscle Contraction
Myocardial Contraction
Physical Exertion*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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