Document Detail

Effects of isoflurane on nitric oxide metabolism and oxidant status of guinea pig myocardium.
MedLine Citation:
PMID:  11152023     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Volatile anesthetics (VAs) have been shown to enhance myocardial recovery during reperfusion, the mechanism of which has not been clarified yet. It has been supposed that this effect of VAs may appear through antioxidative mechanisms. METHODS: Thirty guinea pigs were used in the study. There were three groups with 10 animals in each: I - control, II - isoflurane+oxygen and III - oxygen. Isoflurane (2.0% v/v) and oxygen (100%) mixture was given to the animals via a face mask in the isoflurane+oxygen group at the rate of 21 per min for 30 min a day for three consecutive days. In the oxygen group, oxygen alone (100%) was given under the same conditions as in the isoflurane+oxygen group. At the end of the experiments, the animals were killed and their hearts were removed. In the heart tissues, nitric oxide synthase (NOS) activity, nitric oxide (NO) pool (NO*+NO2-) and malondialdehyde (MDA) levels were measured. RESULTS: NOS activity was found to be higher and the NO pool lower in the isoflurane+oxygen group compared with those of control and oxygen groups. In the oxygen group, MDA level was found to be higher compared to the other groups. There was, however, no significant difference between MDA levels of the control and isoflurane+oxygen groups. CONCLUSION: Our results suggest that isoflurane prevents peroxidation reactions in heart tissue, possibly by scavenging toxic oxygen radicals produced under hyperoxygenation conditions as occurs with general anesthesia.
I Durak; M Kavutcu; M Kaçmaz; A Avci; E Horasanli; B Dikmen; M Y Cimen; H S Oztürk
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Acta anaesthesiologica Scandinavica     Volume:  45     ISSN:  0001-5172     ISO Abbreviation:  Acta Anaesthesiol Scand     Publication Date:  2001 Jan 
Date Detail:
Created Date:  2001-01-09     Completed Date:  2001-03-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370270     Medline TA:  Acta Anaesthesiol Scand     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  119-22     Citation Subset:  IM    
Department of Biochemistry, Medical Faculty, Ankara University, Turkey.
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MeSH Terms
Anesthetics, Inhalation / pharmacology*
Guinea Pigs
Heart / drug effects
Hydrogen-Ion Concentration
Isoflurane / pharmacology*
Malondialdehyde / metabolism
Myocardium / metabolism*
Nitric Oxide / metabolism*
Nitric Oxide Synthase / metabolism
Oxidants / metabolism*
Reg. No./Substance:
0/Anesthetics, Inhalation; 0/Oxidants; 10102-43-9/Nitric Oxide; 26675-46-7/Isoflurane; 542-78-9/Malondialdehyde; EC Oxide Synthase

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