Document Detail

Effects of isoflurane, enflurane, and halothane on skeletal muscle microcirculation in the endotoxemic rat.
MedLine Citation:
PMID:  11230718     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The cardiovascular effects of volatile anesthetics during sepsis sets patients at high risk for hemodynamic deterioration. We compared the microcirculatory alterations in skeletal muscle under anesthesia with isoflurane, enflurane, and halothane in an endotoxemic rat preparation. MATERIALS AND METHODS: Twenty-one Sprague-Dawley rats under continuous hemodynamic monitoring and intravital microscopy of the spinotrapezius muscle were studied during two level lipopolysaccharide (0.2 mg/kg and 2 mg/kg) induced sepsis. The effects of equianesthetic concentrations (1.5 minimum alveolar concentration [MAC]) of either isoflurane [n:7], enflurane [n:7], or halothane [n:7] on microcirculatory vasoregulation were measured and histopathologic changes were evaluated. RESULTS: During low-dose endotoxemia, arteriolar vasodilation under isoflurane was nearly abolished (P < .05). At high-dose endotoxemia, this lack of vasodilatory effect was similar (P < .05). Animals receiving 1.5 MAC of enflurane during low-dose endotoxin presented a significant decrease in arteriolar diameter by -11.3 (+/-2.9%), this response was less during high-dose endotoxemia (-7.0, +/-2.9%). Halothane caused pronounced vasoconstriction by -20 (+/-3.7%) during low-dose endotoxemia and moderate but significant constriction during high-dose endotoxemia (-7.9, +/-2.6%). CONCLUSIONS: Isoflurane, enflurane, and halothane exert significantly different effects on vasoregulation of skeletal muscle arterioles in the endotoxemic rat.
J Schumacher; M Pörksen; K F Klotz
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of critical care     Volume:  16     ISSN:  0883-9441     ISO Abbreviation:  J Crit Care     Publication Date:  2001 Mar 
Date Detail:
Created Date:  2001-04-05     Completed Date:  2001-07-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8610642     Medline TA:  J Crit Care     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1-7     Citation Subset:  IM    
Department of Anesthesiology, Medical University of Luebeck, Germany.
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MeSH Terms
Anesthetics, Inhalation / pharmacology*
Endotoxemia / pathology,  physiopathology*
Enflurane / pharmacology
Halothane / pharmacology
Hemodynamics / drug effects
Isoflurane / pharmacology
Microcirculation / drug effects
Muscle, Skeletal / drug effects*
Rats, Sprague-Dawley
Reg. No./Substance:
0/Anesthetics, Inhalation; 13838-16-9/Enflurane; 151-67-7/Halothane; 26675-46-7/Isoflurane

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