Document Detail

Effects of isoflurane on echocardiographic parameters in healthy dogs.
MedLine Citation:
PMID:  18282260     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To study the echocardiographic effects of isoflurane at an end-tidal concentration approximating 1.0 times the minimum alveolar concentration (MAC) in healthy unpremedicated dogs. STUDY DESIGN: Prospective experimental trial. ANIMALS: Sixteen mature mongrel dogs of either sex weighing 11.06 +/- 2.72 kg. METHODS: After performing a baseline echocardiogram in the awake animal, anesthesia was induced with increasing inspired concentrations of isoflurane via a face mask until tracheal intubation was possible. Following intubation, the end-tidal concentration was decreased to 1.4% for the rest of the anesthetic period. Serial echocardiograms were recorded at 25, 40, and 55 minutes after the end-tidal concentration was reached. RESULTS: No changes were observed in heart rate. However, significant decreases were seen in left ventricular end-diastolic diameter (Mean maximal change: 13.8%), interventricular septal thickness during systole (15.2%), interventricular septal thickening fraction (72.2%), left ventricular free wall thickening fraction (63.5%), ejection fraction (39.9%), and fractional shortening (46.7%). In addition, peak flow velocities across mitral, pulmonic, and aortic valves were significantly lower than baseline values. Decreases were also observed in end-diastolic left ventricular volume index (approximately 32.1% from the awake value), stroke index (58.2%), and cardiac index (55.3%) when compared with awake measurements. CONCLUSIONS: and clinical relevance Our results indicate that 1 x MAC isoflurane caused significant myocardial depression in healthy dogs. These changes in myocardial function need to be considered carefully when isoflurane is to be used in dogs with poor cardiovascular reserve.
Marlos G Sousa; Roberta Carareto; Andrigo B De-Nardi; Fábio L C Brito; Newton Nunes; Aparecido A Camacho
Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-02-18
Journal Detail:
Title:  Veterinary anaesthesia and analgesia     Volume:  35     ISSN:  1467-2995     ISO Abbreviation:  Vet Anaesth Analg     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-05-07     Completed Date:  2008-10-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100956422     Medline TA:  Vet Anaesth Analg     Country:  England    
Other Details:
Languages:  eng     Pagination:  185-90     Citation Subset:  IM    
Department of Veterinary Medicine and Surgery, College of Agricultural and Veterinarian Sciences, São Paulo State University, São Paulo, Brazil.
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MeSH Terms
Anesthesia, Inhalation / veterinary
Anesthetics, Inhalation / pharmacology*
Echocardiography / drug effects,  veterinary*
Heart Rate / drug effects
Isoflurane / pharmacology*
Reg. No./Substance:
0/Anesthetics, Inhalation; 26675-46-7/Isoflurane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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