Document Detail

Effects of isoflurane on brain stem blood flow and renal sympathetic nerve activity during induced hypotension.
MedLine Citation:
PMID:  9380769     Owner:  NLM     Status:  MEDLINE    
Effects of isoflurane on arterial blood pressure, regional blood flow in the brain stem, and renal sympathetic nerve activity were compared with those during vasodilator-induced hypotension using decerebrate unanesthetized cats. Either prostaglandin E1 (PGE1) or trinitroglycerin (TNG) was used to decrease the mean arterial pressure 30% below the control level. The effects of isoflurane (0.5 MAC for 15 min) were examined in the following three conditions: (1) during PGE1-induced hypotension; (2) during TNG-induced hypotension, and (3) without either vasodilator. Isoflurane decreased the brain stem blood flow in parallel with a systemic blood pressure fall. Electrical activity of the renal sympathetic nerve consisted of a high-amplitude phasic and a low-amplitude tonic discharge. Isoflurane decreased the phasic activity and increased the tonic activity. Although the two vasodilators had a similar effect on systemic blood pressure and renal sympathetic discharge, TNG decreased the brain stem blood flow to a lesser extent than PGE1. However, the effects of isoflurane on all parameters were statistically identical in the three conditions not treated and pretreated with either vasodilator. Also, the blood concentrations of isoflurane did not differ among the three conditions. The present study demonstrates that isoflurane produces similar effects on systemic blood pressure, regional cerebral blood flow and sympathetic efferent discharge during vasodilator-induced hypotension and without any vasodilator.
M Kiriyama; A Haji; A Masuda; Y Ito; R Takeda
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Pharmacology     Volume:  54     ISSN:  0031-7012     ISO Abbreviation:  Pharmacology     Publication Date:  1997 May 
Date Detail:
Created Date:  1997-11-12     Completed Date:  1997-11-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0152016     Medline TA:  Pharmacology     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  232-40     Citation Subset:  IM    
Department of Anesthesiology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan.
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MeSH Terms
Alprostadil / administration & dosage,  pharmacology
Analysis of Variance
Anesthetics, Inhalation / administration & dosage,  blood,  metabolism,  pharmacology*
Blood Pressure / drug effects
Brain Stem / blood supply*,  drug effects
Cerebrovascular Circulation / drug effects*
Decerebrate State
Electric Stimulation
Hypotension / chemically induced,  physiopathology*
Isoflurane / administration & dosage,  blood,  metabolism,  pharmacology*
Kidney / drug effects,  innervation*,  physiopathology
Medulla Oblongata / drug effects,  pathology
Nitroglycerin / administration & dosage,  pharmacology
Statistics as Topic
Sympathetic Nervous System / drug effects*,  physiopathology
Vasodilator Agents / administration & dosage,  pharmacology
Reg. No./Substance:
0/Anesthetics, Inhalation; 0/Vasodilator Agents; 26675-46-7/Isoflurane; 55-63-0/Nitroglycerin; 745-65-3/Alprostadil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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