Document Detail


Effects of isoflavones containing soy protein isolate compared with fish protein on serum lipids and susceptibility of low density lipoprotein and liver lipids to in vitro oxidation in hamsters.
MedLine Citation:
PMID:  15539259     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
The effects of dietary soy protein isolate (SPI), ethanol-extracted SPI (E-SPI) low in isoflavones, and fish protein (FP) on the concentration of blood lipids and the susceptibility of low density lipoprotein (LDL) to copper-induced oxidation were compared in male golden Syrian hamsters fed a moderate hypercholesterolemic semi-purified diet for 10 weeks. SPI, E-SPI, and FP were incorporated into the isonitrogenous experimental diets as protein sources. The SPI group exhibited significantly lower serum total cholesterol concentration compared with the E-SPI group (P < 0.05) and the FP group (P < 0.01). Both the SPI and E-SPI groups showed lower LDL cholesterol (P < 0.001 and P < 0.05, respectively) and less LDL apolipoprotein B (P < 0.01) compared with the FP group. The distribution pattern of serum lipoprotein cholesterol fractions of the SPI and E-SPI groups were similar to each other, but different from that of the FP group. The lysine/arginine ratio of the three diets was significantly correlated with serum total cholesterol concentration (r = 0.462, P = 0.023). The resistance of LDL to copper-induced oxidation was greater in the SPI group than in the E-SPI and FP groups as assessed by the lower concentrations of thiobarbituric acid-reactive substances (TBARS) and the longer lag time required for the formation of conjugated dienes (P < 0.01). Livers of hamsters fed the FP diet had a higher amount of TBARS than those of hamsters fed SPI (P < 0.01) and E-SPI (P < 0.05) diets. The SPI diet showed sparing effects on alpha-tocopherol contents in both serum and liver. It seems likely that soy isoflavones protect the circulating and membrane lipids by sparing alpha-tocopherol and endogenous antioxidants.
Authors:
P J Tsai; P C Huang
Related Documents :
7884539 - Soy consumption and cholesterol reduction: review of animal and human studies.
25170869 - Long-term low carbohydrate diet leads to deleterious metabolic manifestations in diabet...
9252929 - Estrogen-androgen for hormone replacement. a review.
11786089 - Protective effects of a soy diet in preventing obesity-linked renal disease.
19563599 - J. cosmet. sci., 59, 217-224 (may/june 2008) in vivo spectrophotometric evaluation of s...
10568469 - Effects of replacing fish meal with soy protein concentrate and of dl-methionine supple...
3621949 - Lipid markers, coronary score and coronary artery disease of stable angina pectoris type.
21282049 - Abresham ameliorates dyslipidemia, hepatic steatosis and hypertension in high-fat diet ...
17235109 - Contribution of plasma lipid disturbances to vascular endothelial function in patients ...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of nutritional biochemistry     Volume:  10     ISSN:  0955-2863     ISO Abbreviation:  J. Nutr. Biochem.     Publication Date:  1999 Nov 
Date Detail:
Created Date:  2004-11-12     Completed Date:  2005-03-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9010081     Medline TA:  J Nutr Biochem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  631-7     Citation Subset:  -    
Affiliation:
Department of Biochemistry, College of Medicine, National Taiwan University, Taipei, Taiwan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Effects of dietary supplementation with sea buckthorn (Hippophaë rhamnoides) seed and pulp oils on a...
Next Document:  Effect of delta22-5beta-taurocholenic acid on hepatic cholesterol and fatty acid in gold thioglucose...