Document Detail

Effects of ischemic preconditioning on myocardial protective on cardiac surgery: possibility of ischemic preconditioning and adenosine administration.
MedLine Citation:
PMID:  14672527     Owner:  NLM     Status:  MEDLINE    
SUBJECT: We evaluated the efficacy for concomitant use of ischemic preconditioning (IPC) and cardioplegic arrest with adenosine premedication on myocardial protection. METHODS: Twenty-one pigs were divided into three groups: 1) control group, 2) IPC group which had IPC, 3) IPC+adenosine triphosphate (ATP) group which had an administration of 140 gamma of ATP (Adetphos, Kowa, Tokyo, Japan) during IPC. IPC was employed by 3 minutes of aortic cross clamping and 5 minutes of reperfusion. After cardioplegic arrest, the hemodynamical state was observed during 60 minutes of reperfusion. Serum adenosine, troponin-T, E-max, and Tau (the time constant of early diastolic left ventricular pressure decay) were compared. RESULTS: Serum adenosine levels and at the end of IPC and 60 minutes reperfusion were significantly higher in the IPC and IPC+ATP groups than the control group. Comparison of the myocardial contractile force indicator E-max showed that the IPC and IPC+ATP groups showed significantly higher recovery rates of myocardial contractile force than the control group. Tau was the lowest in the IPC+ATP group than the other groups. In the histopathological study, the control group showed widely distributed hypercontraction bands and waving degeneration of myofibrils. On the other hand, the structure of myofibrils was well preserved in the IPC and IPC+ATP groups. CONCLUSIONS: The concomitant use of IPC enhanced the effect of a myocardial protective solution. However, the administration of adenosine during IPC did not show any further advantage than IPC along. (Ann Thorac Cardiovasc Surg 2003; 9: 307-13)
Michio Funahashi
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia     Volume:  9     ISSN:  1341-1098     ISO Abbreviation:  Ann Thorac Cardiovasc Surg     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2003-12-15     Completed Date:  2004-02-26     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  9703158     Medline TA:  Ann Thorac Cardiovasc Surg     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  307-13     Citation Subset:  IM    
Second Department of Surgery, Nihon University School of Medicine, Tokyo, Japan.
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MeSH Terms
Adenosine / analysis,  pharmacology*
Biopsy, Needle
Cardiac Surgical Procedures / methods
Combined Modality Therapy
Disease Models, Animal
Heart Arrest, Induced / methods
Ischemic Preconditioning, Myocardial / methods*
Myocardial Contraction / physiology
Myocardial Reperfusion Injury / pathology*,  prevention & control*
Postoperative Complications / prevention & control
Random Allocation
Reference Values
Risk Assessment
Sensitivity and Specificity
Sus scrofa
Treatment Outcome
Troponin T / analysis
Reg. No./Substance:
0/Troponin T; 58-61-7/Adenosine

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