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Effects of iron supplementation on red blood cell hemoglobin content in pregnancy.
MedLine Citation:
PMID:  23355942     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Although a mild degree of anemia is common in the third trimester of pregnancy, it remains a challenge to establish whether a decrease in hemoglobin (Hb) concentration is physiological or pathological. The World Health Organization suggested a Hb concentration of 110 g/L to discriminate anemia. Several European investigators recommended Hb cut-off values of between 101-110 g/L. The aim of this study was to establish short-term effects of iron supplementation on the hemoglobin content of reticulocytes (Ret-He) and red blood cells (RBC-He) in case of suspected iron deficient erythropoiesis (IDE) in the third trimester of pregnancy. Twenty-five subjects with suspected IDE during pregnancy (Hb ≤110g/L, Ret-He <29.6 pg, zinc protoporphyrin >75 mol/mol hem) participated in the study. After iron supplementation, reticulocyte counts increased from 0.061±0.015×10(12)/L to 0.079±0.026×10(12)/L and Ret-He increased from 23.6±2.8 pg to 28.3±2.6 pg (P=<0.001). RBC-He increased from 26.9±1.9 pg to 27.4±1.8 pg (not significant, NS) and Ret-He/RBC-He ratio increased from 0.97±0.06 towards 1.07±0.05 (P=<0.001). Hb concentrations demonstrated an obvious increase from 105±6 g/L towards 115±5 g/L (P≤0.001) after supplementation. An obvious increase in RBC distribution width was observed from 45.0±3.6 fL towards 52.3±7.0 fL (P≤0.001). We recommend that Ret-He and Ret-He/RBC-He ratio be integrated into the protocols for anemia screening and for monitoring effects of iron supplementation during pregnancy. In particular, the parameters should be considered in subjects with Hb results in the controversial range of 101-108 g/L.
Authors:
Margreet Schoorl; Marianne Schoorl; Derek van der Gaag; Piet C M Bartels
Publication Detail:
Type:  Journal Article     Date:  2012-11-28
Journal Detail:
Title:  Hematology reports     Volume:  4     ISSN:  2038-8322     ISO Abbreviation:  Hematol Rep     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2013-01-28     Completed Date:  2013-01-29     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  101556723     Medline TA:  Hematol Rep     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  e24     Citation Subset:  -    
Affiliation:
Department of Clinical Chemistry, Haematology and Immunology, Medical Center Alkmaar, The Netherlands.
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