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Effects of iron supplementation on auditory brainstem response in marginally LBW infants.
MedLine Citation:
PMID:  21857390     Owner:  NLM     Status:  Publisher    
Low birth weight infants are at risk of iron deficiency (ID), which is associated with impaired nervous system development and may lead to prolonged auditory brainstem response (ABR) latencies. We hypothesized that iron supplementation shortens ABR latencies in marginally low birth weight (MLBW, 2000-2500g) infants. In a randomized, controlled trial, 285 healthy MLBW infants received 0, 1, or 2 mg iron/kg/day of iron supplements from six weeks to six months of age. ABR absolute wave V latencies and central conduction time (CCT) were measured at the endpoint. There were no significant differences between groups in ABR wave V latencies (n=218). Furthermore, there were no significantly prolonged ABR latencies in infants with ID (n=32). CCT was significantly higher in the 2 mg-group than in the placebo-group (n=126). However, there were no significant correlations between CCT and iron intake or any iron status variable, suggesting that differences in CCT were not caused by iron. We conclude that iron supplements did not improve ABR latencies and iron deficient MLBW infants did not have impaired ABR latencies at six months, suggesting that ABR is not a sensitive measure of impaired neurological development or that mild/moderate ID causes no such impairment in MLBW infants. ABBREVIATIONS:
Staffan K Berglund; Björn Westrup; Elisabet Haraldsson; Berit Engström; Magnus Domellöf
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-8-18
Journal Detail:
Title:  Pediatric research     Volume:  -     ISSN:  1530-0447     ISO Abbreviation:  -     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-8-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Clinical Sciences, Pediatrics [S.K.B., M.D.], Umeå University, SE-901 85 Umeå, Sweden; Department of Women and Child Health [B.W.], Karolinska Institute, SE-182 88 Stockholm, Sweden; Department of Audiology [E.H., B.E.], Karolinska Hospital, SE-171 76 Stockholm, Sweden.
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