| Effects of iron-binding proteins on in vitro uptake of 67Ga-citrate by tumor cells. | |
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MedLine Citation:
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PMID: 2341289 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A comparative study of carrier-free 67Ga-citrate uptake by Ehrlich ascites tumor cells in the presence of lactoferrin, transferrin and ferritin has demonstrated that lactoferrin considerably increases the uptake of 67Ga, and that this increase seems to be determined by its iron-load. The other iron-binding proteins assayed have a null or negative effect. Their behavior in the presence of sodium citrate supports the concept of lactoferrin-binding by the cells as responsible for the uptake. The different behavior of 67Ga-citrate iron-binding protein complexes appears to support this hypothesis. |
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Authors:
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L J Anghileri; P Thouvenot; F Brunotte; M C Crone Escanye; J Robert |
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Publication Detail:
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Type: Comparative Study; In Vitro; Journal Article |
Journal Detail:
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Title: International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology Volume: 17 ISSN: 0883-2897 ISO Abbreviation: Int J Rad Appl Instrum B Publication Date: 1990 |
Date Detail:
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Created Date: 1990-06-26 Completed Date: 1990-06-26 Revised Date: 2008-02-21 |
Medline Journal Info:
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Nlm Unique ID: 8611098 Medline TA: Int J Rad Appl Instrum B Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 331-4 Citation Subset: IM |
Affiliation:
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Nuclear Medicine Service, Faculty of Medicine, University of Nancy, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carcinoma, Ehrlich Tumor / metabolism*, radionuclide imaging Citrates / pharmacokinetics* Citric Acid Ferritins / pharmacology* Gallium Radioisotopes / diagnostic use Lactoferrin / pharmacology* Lactoglobulins / pharmacology* Transferrin / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Citrates; 0/Gallium Radioisotopes; 0/Lactoferrin; 0/Lactoglobulins; 11096-37-0/Transferrin; 77-92-9/Citric Acid; 9007-73-2/Ferritins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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