Document Detail


Effects of iodine repletion on thyroid morphology in iodine and/or selenium deficient rat term fetuses, pups and mothers.
MedLine Citation:
PMID:  10403179     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It has been suggested that selenium deficiency aggravates the iodine-induced thyroid inflammation and necrosis in iodine-deficient Wistar rats and possibly in man. Studies were carried out to determine whether large amounts of iodine given to iodine-deficient pregnant Sprague-Dawley rats with or without selenium deficiency would induce inflammation and necrosis in their term fetal thyroids. Iodine deficiency was induced in the dams by a low iodine diet or perchlorate in the drinking water and iodine excess was achieved by iodinated drinking water during pregnancy or daily subcutaneous injections of iodine from days 20 to 22 of pregnancy, 1 day after perchlorate was discontinued. Studies were also carried out in 30-day-old pups whose nursing mothers were iodine-deficient (perchlorate) with or without selenium deficiency from conception onward. The administration of iodine restored the morphologic changes in the thyroid induced by iodine deficiency, irrespective of selenium status, toward normal without inflammatory changes or necrosis. Possible explanations for these unexpected findings are discussed.
Authors:
R M Colzani; S Alex; S L Fang; S Stone; L E Braverman
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biochimie     Volume:  81     ISSN:  0300-9084     ISO Abbreviation:  Biochimie     Publication Date:  1999 May 
Date Detail:
Created Date:  1999-09-02     Completed Date:  1999-09-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  1264604     Medline TA:  Biochimie     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  485-91     Citation Subset:  IM    
Affiliation:
Brigham and Women's Hospital, Boston, MA 02115, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Female
Iodine / metabolism,  physiology*
Male
Organ Size
Pregnancy
Rats
Rats, Sprague-Dawley
Selenium / metabolism,  physiology*
Thyroid Gland / embryology,  pathology*
Thyrotropin / blood
Thyroxine / blood
Triiodothyronine / blood
Grant Support
ID/Acronym/Agency:
DK 18919/DK/NIDDK NIH HHS; DK T-07302/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
6893-02-3/Triiodothyronine; 7488-70-2/Thyroxine; 7553-56-2/Iodine; 7782-49-2/Selenium; 9002-71-5/Thyrotropin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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