| Effects of iodinated fatty acid ester on human hepatocellular carcinoma cells. | |
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MedLine Citation:
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PMID: 1652177 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The interaction between Lipiodol and cells was studied by treating Lipiodol in a human hepatocellular carcinoma cell line(Hep) and mouse fibroblast cell line (L929). Irregular, sustained radioactivity was released from both cell lines shortly after incubation in the radioiodinated Lipiodol mixed media. Lipiodol droplets were found to be firmly attached to the cells following the incubation and these cells were strongly positive for fat stains. The radioiodinated Lipiodol demonstrated the same behavior of accumulation within the cell and on the cell membrane. Although the amount of Lipiodol attached was almost equal in both of the cell lines, the final amount accumulated in the cells was larger in the Hep cells. The accumulation of Lipiodol within the cell and on the cell membrane may play a significant role for its selective targeting and its prolonged retention in the solid tumor. |
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Authors:
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H Kim; C Park; Y B Lee; H S Yoo; J H Park; W Y Lee |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Yonsei medical journal Volume: 32 ISSN: 0513-5796 ISO Abbreviation: Yonsei Med. J. Publication Date: 1991 Mar |
Date Detail:
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Created Date: 1991-09-24 Completed Date: 1991-09-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0414003 Medline TA: Yonsei Med J Country: KOREA |
Other Details:
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Languages: eng Pagination: 16-23 Citation Subset: IM |
Affiliation:
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Department of Pathology, Wonju Medical College Yonsei University, Korea. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Carcinoma, Hepatocellular
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pathology*,
therapy Humans Iodine Radioisotopes / diagnostic use, therapeutic use Iodized Oil / pharmacokinetics, pharmacology*, therapeutic use Liver Neoplasms / pathology*, therapy Tumor Cells, Cultured / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Iodine Radioisotopes; 8001-40-9/Iodized Oil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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