| Effects of intravitreal bevacizumab (Avastin) therapy on retrobulbar blood flow parameters in patients with neovascular age-related macular degeneration. | |
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MedLine Citation:
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PMID: 19953626 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: To investigate the effects of intravitreal bevacizumab on retrobulbar circulation in patients with neovascular age-related macular degeneration (AMD). METHOD: Thirty patients with neovascular age-related macular degeneration were assessed prospectively by both color Doppler imaging and fundus fluorescein angiography. Spectral Doppler analysis allowed the measurement of the maximum velocity (Vmax) and minimum velocity (Vmin) of the central retinal vein (CRV), and peak systolic (PSV), end-diastolic (EDV) velocities of blood flows, and pulsatility index (PI) and resistance index (RI) values in the central retinal artery (CRA), nasal and temporal posterior ciliary arteries (NPCA, TPCA), and ophthalmic artery (OA). The t test for paired samples was used to compare retrobulbar blood flow values before and after intravitreal bevacizumab injection. RESULT: PSV and EDV of the NPCA and PSV of the TPCA were significantly decreased after intravitreal bevacizumab injection (p < 0.05). There was no statistically significant difference in the other parameters. CONCLUSION: Our results suggest that intravitreal bevacizumab therapy has a measurable effect on retrobulbar blood flow. |
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Authors:
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Ahmet Mete; Oguzhan Saygili; Alper Mete; Metin Bayram; Necdet Bekir |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of clinical ultrasound : JCU Volume: 38 ISSN: 1097-0096 ISO Abbreviation: J Clin Ultrasound Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-01-13 Completed Date: 2010-04-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401663 Medline TA: J Clin Ultrasound Country: United States |
Other Details:
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Languages: eng Pagination: 66-70 Citation Subset: IM |
Copyright Information:
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(c) 2009 Wiley Periodicals, Inc. |
Affiliation:
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Gaziantep University Medical School, Department of Radiology, Sahinbey, Gaziantep, Turkey. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Angiogenesis Inhibitors / administration & dosage* Antibodies, Monoclonal / administration & dosage* Blood Flow Velocity / drug effects*, physiology Female Follow-Up Studies Humans Injections Macular Degeneration / complications, diagnosis, drug therapy* Male Middle Aged Ophthalmic Artery / physiopathology, ultrasonography* Prospective Studies Regional Blood Flow / drug effects*, physiology Retinal Artery / physiopathology, ultrasonography Retinal Neovascularization / diagnosis, drug therapy*, etiology Retinal Vein / physiopathology, ultrasonography Treatment Outcome Ultrasonography, Doppler, Color / methods Vascular Endothelial Growth Factor A / antagonists & inhibitors Vitreous Body |
| Chemical | |
Reg. No./Substance:
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0/Angiogenesis Inhibitors; 0/Antibodies, Monoclonal; 0/Vascular Endothelial Growth Factor A; 0/bevacizumab |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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