| Effects of intraventricular beta-endorphin and D-ALA2-methionine-enkephalinamide on behaviour, spectrum power of electrocortical activity and body temperature in chicks. | |
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MedLine Citation:
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PMID: 7394325 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In chicks (Gallus domesticus) the effects of beta-endorphin and D-Ala-2-methionine-enkephalinamide given into the third cerebral ventricle on behaviour, electrocortical activity and body temperature were studied. Dose-dependent behavioural stuporous state, decrease in painful stimuli and hypothermic effects were observed after both peptides. Electrocortical high-amplitude slow frequency waves occurred during behavioural sedation and stupor. Spectrum power analysis has allowed to quantify the ECoG activity and has revealed an increase in total voltage output with a predominant increase within the lower spectrum frequencies. The hypothermic effects were significantly more marked when chicks were kept at ambient temperature below their thermoneutral range. Behavioural, electrocortical and body temperature effects were rapidly reversed by naloxone showing that these effects are mediated through an activation of specific opioid receptors. |
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Authors:
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G Nisticõ; D Rotiroti; F Naccari; G B De Sarro; E Marmo |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Research communications in chemical pathology and pharmacology Volume: 28 ISSN: 0034-5164 ISO Abbreviation: Res. Commun. Chem. Pathol. Pharmacol. Publication Date: 1980 May |
Date Detail:
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Created Date: 1980-09-26 Completed Date: 1980-09-26 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0244734 Medline TA: Res Commun Chem Pathol Pharmacol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 295-308 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Behavior, Animal / drug effects* Body Temperature / drug effects* Chickens Electroencephalography* Endorphins / administration & dosage, pharmacology* Enkephalin, Methionine* / analogs & derivatives* Enkephalins / administration & dosage, pharmacology* Injections, Intraventricular Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Endorphins; 0/Enkephalins; 58569-55-4/Enkephalin, Methionine; 61090-95-7/enkephalinamide-Met, Ala(2)- |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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