| Effects of intravenous sulfide during porcine aortic occlusion-induced kidney ischemia/reperfusion injury. | |
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MedLine Citation:
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PMID: 20661185 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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In rodents, inhaled H2S and injection of H2S donors protected against kidney ischemia/reperfusion (I/R) injury. During porcine aortic occlusion, the H2S donor Na2S (sulfide) reduced energy expenditure and decreased the noradrenaline requirements needed to maintain hemodynamic targets during early reperfusion. Therefore, we tested the hypothesis whether sulfide pretreatment may also ameliorate organ function in porcine aortic occlusion-induced kidney I/R injury. Anesthetized, ventilated, and instrumented pigs randomly received either sulfide or vehicle and underwent 90 min of kidney ischemia using intraaortic balloon-occlusion, and 8 h of reperfusion. During reperfusion, noradrenaline was titrated to maintain blood pressure at baseline levels. Sulfide attenuated the fall in creatinine clearance and the rise in creatinine blood levels, whereas renal blood flow and fractional Na excretion were comparable. Sulfide also lowered the blood IL-6, IL-1β, and nitrite + nitrate concentrations, which coincided with reduced kidney oxidative DNA base damage and iNOS expression, and attenuated glomerular histological injury as assessed by the incidence of glomerular tubularization. While expression of heme oxygenase 1 and cleaved caspase 3 did not differ, sulfide reduced the expression Bcl-xL and increased the activation of nuclear transcription factor κB. During porcine aortic occlusion-induced kidney I/R injury, sulfide pretreatment attenuated tissue injury and organ dysfunction as a result of reduced inflammation and oxidative and nitrosative stress. The higher nuclear transcription factor κB activation was probably due to the drop in temperature. |
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Authors:
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Florian Simon; Angelika Scheuerle; Michael Gröger; Bettina Stahl; Ulrich Wachter; Josef Vogt; Günter Speit; Balázs Hauser; Peter Möller; Enrico Calzia; Csaba Szabó; Hubert Schelzig; Michael Georgieff; Peter Radermacher; Florian Wagner |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Shock (Augusta, Ga.) Volume: 35 ISSN: 1540-0514 ISO Abbreviation: Shock Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9421564 Medline TA: Shock Country: United States |
Other Details:
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Languages: eng Pagination: 156-63 Citation Subset: IM |
Affiliation:
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*Sektion Anästhesiologische Pathophysiologie und Verfahrensentwicklung, Klinik für Anästhesiologie, †Abteilung für Thorax und Gefässchirurgie, ‡Abteilung Pathologie, and §Institut für Humangenetik, Universitätsklinikum, Ulm, Germany; and ∥Department of Anesthesiology, University of Texas Medical Branch, Galveston, Texas. |
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