| Effects of intravenous pentafraction on lung and soft tissue liquid exchange in hypoproteinemic sheep. | |
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MedLine Citation:
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PMID: 7694507 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Effects of infusing pentafraction (Pen), a synthetic hydroxyethyl starch plasma volume expander, on lung and soft tissue lymph flux were compared in nonanesthetized sheep that were protein depleted by batch plasmapheresis. Pen (5%) was infused to raise pulmonary arterial wedge pressure by 5 mmHg for 2 h (1.8 +/- 0.3 l). Pen raised plasma osmotic pressure from plasmapheresis baseline (10.7 +/- 2.2 mmHg; preplasmapheresis baseline, 19.6 +/- 0.6 mmHg) to 16.6 +/- 2.4 mmHg. After Pen, lung lymph flows peaked at 3.9 +/- 2.0 times a preplasmapheresis baseline value of 1.0 (plasmapheresis baseline, 2.7 +/- 0.7), but soft tissue lymph flows rose insignificantly. Plasma Pen concentrations were 2.3 +/- 1.0% postinfusion and 1.6 +/- 0.3% at 12 h. Pen mean molecular masses at these times, measured by high-performance liquid chromatography, were 160 +/- 44 and 129 +/- 23 kDa, respectively. In lung lymph, Pen concentrations were 0.8 +/- 0.6% postinfusion and 0.7 +/- 0.2% at 12 h, with mean molecular masses of 125 +/- 44 and 112 +/- 18 kDa, respectively. In soft tissue lymph Pen was nearly undetectable postinfusion, but at 12 h concentrations averaged 0.3 +/- 0.2% with a mean molecular mass of 80 +/- 10 kDa. The osmotic effectiveness of Pen may be related to its molecular mass, which was large enough to restrict filtration so that the plasma-to-lung lymph osmotic pressure gradient widened. Pen remained effective in the circulation for at least 24 h. |
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Authors:
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R L Conhaim; D J Rosenfeld; M A Schreiber; D M Baaske; B A Harms |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: The American journal of physiology Volume: 265 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1993 Nov |
Date Detail:
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Created Date: 1993-12-20 Completed Date: 1993-12-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: H1536-43 Citation Subset: IM |
Affiliation:
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Department of Surgery, University of Wisconsin-Madison. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Proteins / drug effects, metabolism* Hetastarch / administration & dosage, pharmacology* Hypoproteinemia / blood, physiopathology* Infusions, Intravenous Lung / drug effects, physiopathology* Lymph / drug effects, physiology* Lymph Nodes / drug effects, physiopathology* Osmotic Pressure Plasma Substitutes / pharmacology* Plasmapheresis Pulmonary Wedge Pressure / drug effects Sheep |
| Chemical | |
Reg. No./Substance:
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0/Blood Proteins; 0/Plasma Substitutes; 9005-27-0/Hetastarch |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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