Document Detail

Effects of intravenous nitroglycerin on the intracranial pressure and volume pressure response.
MedLine Citation:
PMID:  6402569     Owner:  NLM     Status:  MEDLINE    
Ventricular fluid pressure (VFP) and volume-pressure response were measured during nitroglycerin (NTG) infusion in nine patients anesthetized with N2O and fentanyl. The patients' ventilation was controlled, and PaCO2 was kept at 32 +/- 4 mm Hg. When an infusion of 0.01% NTG was given intravenously to decrease the mean blood pressure to 95.1%, 84.7%, and 78.2% of control, the VFP increased from control levels of 9.94 +/- 2.14 mm Hg to 12.89 +/- 2.25, 15.6 +/- 2.85, and 14.43 +/- 3.45 mm Hg, respectively. The volume-pressure response showed a significant increase when blood pressure decreased to 84.7% and 78.2% of control. These results suggest that intravenous NTG caused an increase in the intracranial pressure and a decrease in the intracranial compliance.
G A Ghani; Y F Sung; M S Weinstein; G T Tindall; A S Fleischer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neurosurgery     Volume:  58     ISSN:  0022-3085     ISO Abbreviation:  J. Neurosurg.     Publication Date:  1983 Apr 
Date Detail:
Created Date:  1983-04-21     Completed Date:  1983-04-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0253357     Medline TA:  J Neurosurg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  562-5     Citation Subset:  AIM; IM    
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MeSH Terms
Blood Pressure / drug effects*
Cerebral Ventricles / drug effects,  physiopathology
Dose-Response Relationship, Drug
Injections, Intravenous
Intracranial Pressure / drug effects*
Middle Aged
Nitroglycerin / administration & dosage,  pharmacology*
Reg. No./Substance:

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