| Effects of intravenous nitroglycerin on hemodynamics and ischemic injury in patients with acute myocardial infarction. | |
| | |
MedLine Citation:
|
PMID: 99309 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In 24 patients with acute myocardial infarction intravenous nitroglycerin in 2 different dosages was administered and the effect on hemodynamics and extent of myocardial ischemia was investigated. According to the initial left ventricular filling pressure (LVFP) the patients were divided in Group I: LVFP below 20 mm Hg (13 patients) and in Group II: LVFP above 20 mm Hg (11 patients). Following an infusion of 3 mg of nitroglycerin in the first and 6 mg in the second hour, a significant decrease (P less than 0.0001) in the filling pressure (in Group I from 15 +/- 4 to 9 +/- 3 (+/-1 SD) and in Group II from 28 +/- 11 to 16 +/- 7 mm Hg) was observed. The mean arterial pressure decreased in both groups by an average of 9 mm Hg. The changes in the heart rate were minimal. The cardiac output decreased in Group I from 4.4 +/- 1.0 to 3.9 +/- 0.8 1/min (P less than 0.005) whereas in the group with left ventricular failure it increased significantly from a lowered initial value (3.4 +/- 1.0 to 4.0 +/- 1.1 1/min) (P less than 0.001). By using precordial mapping for estimation of ischemic injury in 12 patient sigma ST elevation decreased from 14.6 +/- 11.9 to 12.2 +/- 9.8 mV at a dose of 3 mg/h (P less than 0.03). The dose of 6 mg/h, however, was less effective on the extent of myocardial ischemia than 3 mg/h. Thus, the dosage of nitroglycerin may be critical in respect to infarct size, despite the beneficial hemodynamic effects of the drug. |
| | |
Authors:
|
W D Bussmann; H Schöfer; M Kaltenbach |
Related Documents
:
|
2071239 - Association of transient abnormal q-waves during exercise testing with a stenosis of th... 8218129 - Precordial isopotential electrocardiographic mapping and its clinical use in patients w... 2121199 - Rapid resolution of st elevation and prediction of clinical outcome in patients undergo... 2768719 - Derived epicardial potentials differentiate ischemic st depression from st depression s... 7371129 - Ventricular premature complexes in prognosis of angina. 9829879 - The influence of the resolution of reciprocal st segment changes on in-hospital complic... 12365649 - Diagnosis of an isolated persistent left side superior vena cava by contrast echocardio... 2917389 - Hypertrophic cardiomyopathy in the elderly. distinctions from the young based on cardia... 20367659 - Successful catheter ablation and documentation of the activation and propagation patter... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: European journal of cardiology Volume: 8 ISSN: 0301-4711 ISO Abbreviation: Eur J Cardiol Publication Date: 1978 Aug |
Date Detail:
|
Created Date: 1978-11-29 Completed Date: 1978-11-29 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0404054 Medline TA: Eur J Cardiol Country: NETHERLANDS |
Other Details:
|
Languages: eng Pagination: 61-74 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Blood Pressure / drug effects Cardiac Output / drug effects Coronary Disease / drug therapy Drug Administration Schedule Electrocardiography Female Heart Rate / drug effects Hemodynamics / drug effects* Humans Male Middle Aged Myocardial Infarction / drug therapy* Nitroglycerin / pharmacology*, therapeutic use |
| Chemical | |
Reg. No./Substance:
|
55-63-0/Nitroglycerin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Treatment of Prinzmetal's angina due to coronary artery spasm using verapamil: a report of three cas...
Next Document: A comparative study of two methods of measurement of fractional calcium absorption: results in norma...