Document Detail

Effects of intravenous glutamate on substrate availability and utilization across the human heart and leg.
MedLine Citation:
PMID:  2011078     Owner:  NLM     Status:  MEDLINE    
To study the effect of monosodium glutamate on hemodynamics and on substrate metabolism in cardiac and skeletal muscle, an intravenous (IV) dose of 1.2, 2.5, or 5.0 mg/kg body weight was administered to 27 patients during arterial-coronary sinus catheterization (15 patients) or arterial-femoral vein catheterization (13 patients). Data were obtained for 25 minutes after the injection. Arterial glutamate concentrations increased 2.5-5 fold in a dose-related manner. Glutamate administration reduced arterial levels of free fatty acids by 25% (P less than .001), of lactate by 13% (P less than .05), and of alanine by 6% (P less than .05). Arterial glucose increased by 10% (P less than .001) and arterial insulin was increased threefold (P less than .01). Myocardial uptake of free fatty acids decreased by 25% (P less than .001), whereas uptakes of glutamate and glucose increased by 60% (P less than .001) and 100% (P less than .001), respectively. Cardiac release of citrate increased transiently (P less than .05), whereas consumption of lactate and releases of alanine were unchanged by the glutamate. Across the leg, the arteriovenous differences of glutamate were elevated threefold to eightfold (dose-related) (P less than .001), and that of glucose was doubled (P less than .01). The release of citrate increased (P less than .01). Arterial-femoral vein gradients of free fatty acids, lactate, and alanine remained unchanged. Heart rate, blood pressure, coronary sinus flow, coronary vascular resistance, and cardiac oxygen uptake were unmodified by glutamate. Six patients complained of short-lasting burning sensations after the highest glutamate doses. In conclusion, glutamate administration stimulates insulin secretion and changes substrate availability and utilization in human cardiac and skeletal muscle from free fatty acids toward glucose and glutamate.
A Thomassen; T T Nielsen; J P Bagger; P Henningsen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Metabolism: clinical and experimental     Volume:  40     ISSN:  0026-0495     ISO Abbreviation:  Metab. Clin. Exp.     Publication Date:  1991 Apr 
Date Detail:
Created Date:  1991-05-07     Completed Date:  1991-05-07     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0375267     Medline TA:  Metabolism     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  378-84     Citation Subset:  IM    
Department of Cardiology, Skejby Sygehus, Arhus N, Denmark.
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MeSH Terms
Alanine / blood,  metabolism
Blood Glucose / metabolism
Citrates / metabolism
Citric Acid
Fatty Acids, Nonesterified / blood,  metabolism
Glucose / metabolism
Heart / drug effects
Hemodynamics / drug effects
Injections, Intravenous
Insulin / blood
Lactates / blood,  metabolism
Lactic Acid
Middle Aged
Muscles / drug effects,  metabolism*
Myocardium / metabolism*
Sodium Glutamate / administration & dosage,  metabolism,  pharmacology*
Reg. No./Substance:
0/Blood Glucose; 0/Citrates; 0/Fatty Acids, Nonesterified; 0/Lactates; 11061-68-0/Insulin; 142-47-2/Sodium Glutamate; 50-21-5/Lactic Acid; 50-99-7/Glucose; 56-41-7/Alanine; 77-92-9/Citric Acid

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