| Effects of intravenous glutamate on substrate availability and utilization across the human heart and leg. | |
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MedLine Citation:
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PMID: 2011078 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To study the effect of monosodium glutamate on hemodynamics and on substrate metabolism in cardiac and skeletal muscle, an intravenous (IV) dose of 1.2, 2.5, or 5.0 mg/kg body weight was administered to 27 patients during arterial-coronary sinus catheterization (15 patients) or arterial-femoral vein catheterization (13 patients). Data were obtained for 25 minutes after the injection. Arterial glutamate concentrations increased 2.5-5 fold in a dose-related manner. Glutamate administration reduced arterial levels of free fatty acids by 25% (P less than .001), of lactate by 13% (P less than .05), and of alanine by 6% (P less than .05). Arterial glucose increased by 10% (P less than .001) and arterial insulin was increased threefold (P less than .01). Myocardial uptake of free fatty acids decreased by 25% (P less than .001), whereas uptakes of glutamate and glucose increased by 60% (P less than .001) and 100% (P less than .001), respectively. Cardiac release of citrate increased transiently (P less than .05), whereas consumption of lactate and releases of alanine were unchanged by the glutamate. Across the leg, the arteriovenous differences of glutamate were elevated threefold to eightfold (dose-related) (P less than .001), and that of glucose was doubled (P less than .01). The release of citrate increased (P less than .01). Arterial-femoral vein gradients of free fatty acids, lactate, and alanine remained unchanged. Heart rate, blood pressure, coronary sinus flow, coronary vascular resistance, and cardiac oxygen uptake were unmodified by glutamate. Six patients complained of short-lasting burning sensations after the highest glutamate doses. In conclusion, glutamate administration stimulates insulin secretion and changes substrate availability and utilization in human cardiac and skeletal muscle from free fatty acids toward glucose and glutamate. |
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Authors:
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A Thomassen; T T Nielsen; J P Bagger; P Henningsen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Metabolism: clinical and experimental Volume: 40 ISSN: 0026-0495 ISO Abbreviation: Metab. Clin. Exp. Publication Date: 1991 Apr |
Date Detail:
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Created Date: 1991-05-07 Completed Date: 1991-05-07 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375267 Medline TA: Metabolism Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 378-84 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Skejby Sygehus, Arhus N, Denmark. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Alanine / blood, metabolism Arteries Blood Glucose / metabolism Citrates / metabolism Citric Acid Fatty Acids, Nonesterified / blood, metabolism Female Glucose / metabolism Heart / drug effects Hemodynamics / drug effects Humans Injections, Intravenous Insulin / blood Lactates / blood, metabolism Lactic Acid Leg Male Middle Aged Muscles / drug effects, metabolism* Myocardium / metabolism* Sodium Glutamate / administration & dosage, metabolism, pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Citrates; 0/Fatty Acids, Nonesterified; 0/Lactates; 11061-68-0/Insulin; 142-47-2/Sodium Glutamate; 50-21-5/Lactic Acid; 50-99-7/Glucose; 56-41-7/Alanine; 77-92-9/Citric Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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