Document Detail


Effects of intravenous endralazine in essential hypertension.
MedLine Citation:
PMID:  6349669     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of endralazine, administered intravenously, on blood pressure, heart rate, forearm blood flow, plasma renin activity, aldosterone, adrenaline and noradrenaline were studied in five patients with essential hypertension. Endralazine reduced peripheral vascular resistance, resulting in decrease in mean arterial pressure from 141 to 116 mm Hg and increase in heart rate from 67 to 92 beats/min. Plasma renin activity, adrenaline and noradrenaline increased significantly after endralazine infusion. All effects observed are consistent with endralazine acting as a peripheral vasodilating drug.
Authors:
J J Hoffmann; T Thien; A van T'Laar
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of clinical pharmacology     Volume:  16     ISSN:  0306-5251     ISO Abbreviation:  Br J Clin Pharmacol     Publication Date:  1983 Jul 
Date Detail:
Created Date:  1983-10-08     Completed Date:  1983-10-08     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7503323     Medline TA:  Br J Clin Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  39-44     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aldosterone / blood
Antihypertensive Agents / administration & dosage*,  adverse effects
Blood Pressure / drug effects
Epinephrine / blood
Female
Humans
Hypertension / drug therapy*
Male
Middle Aged
Norepinephrine / blood
Pyridazines / administration & dosage*,  adverse effects
Renin / blood
Time Factors
Chemical
Reg. No./Substance:
0/Antihypertensive Agents; 0/Pyridazines; 39715-02-1/BQ 22-708; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 52-39-1/Aldosterone; EC 3.4.23.15/Renin
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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