| Effects of intravenous disopyramide on coronary hemodynamics and vasodilator reserve in hypertrophic obstructive cardiomyopathy. | |
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MedLine Citation:
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PMID: 8631046 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Disopyramide reduces the subaortic pressure gradients and improves the clinical symptoms of patients with hypertrophic obstructive cardiomyopathy. Changes in coronary hemodynamics and vasodilator reserve in response to this agent have not been evaluated in such patients. To assess the acute effects of intravenous administration of disopyramide on coronary hemodynamics, microvascular dilatory capacity, and balance between myocardial oxygen supply and demand in hypertrophic obstructive cardiomyopathy, we examined 12 patients using an intravascular Doppler catheter and spectral analysis. Intravenous disopyramide 100 mg over 10 min caused mild increases in heart rate and aortic systolic pressure and a significant fall in left ventricular systolic pressure, resulting in a 13% decrease in the product of heart rate and left ventricular systolic pressure (from 1.13 +/- 0.18 x 10(4) before disopyramide to 0.98 +/- 0.17 x 10(4) beats/min x mm Hg 10 min afterwards; p < 0.05) and a reduction in the resting peak systolic pressure gradients of the left ventricular outflow tract. There was a 14% reduction in coronary blood flow (from 93.5 +/- 13.2 to 80.3 +/- 11.6 ml/min; p < 0.05) with an increase in coronary resistance (from 0.94 +/- 0.16 to 1.23 +/- 0.21 mm Hg/ml/min; p < 0.001). The index of coronary vasodilator reserve remained unchanged. These findings suggest that intravenous disopyramide causes a coronary vasoconstrictive effect without significantly changing the coronary microvascular dilatory capacity, but this effect may not be harmful to the balance between myocardial oxygen supply and demand in patients with hypertrophic obstructive cardiomyopathy. |
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Authors:
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M Hongo; T Nakatsuka; H Takenaka; M Tanaka; N Watanabe; Y Yazaki; M Sekiguchi |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Cardiology Volume: 87 ISSN: 0008-6312 ISO Abbreviation: Cardiology Publication Date: 1996 Jan-Feb |
Date Detail:
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Created Date: 1996-07-03 Completed Date: 1996-07-03 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1266406 Medline TA: Cardiology Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 6-11 Citation Subset: IM |
Affiliation:
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First Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Analysis of Variance Anti-Arrhythmia Agents / therapeutic use* Blood Flow Velocity Cardiomyopathy, Hypertrophic / drug therapy*, physiopathology Coronary Circulation / drug effects Disopyramide / therapeutic use* Female Heart Catheterization Hemodynamics / drug effects* Humans Infusions, Intravenous Male Middle Aged Vasodilation / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Arrhythmia Agents; 3737-09-5/Disopyramide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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