Document Detail

Effects of intravenous cariporide on norepinephrine and myoglobin releases during myocardial ischemia/reperfusion in rabbits.
MedLine Citation:
PMID:  25139834     Owner:  NLM     Status:  Publisher    
AIMS: To examine the effects of cariporide, a Na(+)/H(+) exchanger-1 inhibitor, on cardiac norepinephrine (NE) and myoglobin releases during myocardial ischemia/reperfusion by applying a microdialysis technique to the rabbit heart.
MAIN METHODS: In anesthetized rabbits, two dialysis probes were implanted into the left ventricular myocardium and were perfused with Ringer's solution. Cariporide (0.3mg/kg) was injected intravenously, followed by occlusion of the left circumflex coronary artery. During 30-min coronary occlusion followed by 30-min reperfusion, four consecutive 15-min dialysate samples (two during ischemia and two during reperfusion) were collected in vehicle and cariporide-treated groups. Dialysate myoglobin and NE concentrations were measured by immunochemistry and high-performance liquid chromatography, respectively.
KEY FINDINGS: Dialysate myoglobin and NE concentrations increased significantly during myocardial ischemia/reperfusion in both vehicle and cariporide-treated groups (P<0.01 vs. baseline). In cariporide-treated group, dialysate myoglobin concentrations were significantly lower than those in vehicle group throughout ischemia/reperfusion (P <0.01 at 0-15min of ischemia, P <0.05 at 15-30min of ischemia, P <0.01 at 0-15min of reperfusion, and P <0.01 at 15-30min of reperfusion). However, dialysate NE concentrations in cariporide-treated group were lower than those in vehicle group only during ischemia (P<0.01 at 0-15min of ischemia, and P <0.05 at 15-30min of ischemia).
SIGNIFICANCE: When administered before ischemia, cariporide reduces myoglobin release during ischemia/reperfusion and decreases NE release during ischemia.
Shigeru Sakurai; Yosuke Kuroko; Shuji Shimizu; Toru Kawada; Tsuyoshi Akiyama; Toji Yamazaki; Masaru Sugimachi; Shunji Sano
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-8-16
Journal Detail:
Title:  Life sciences     Volume:  -     ISSN:  1879-0631     ISO Abbreviation:  Life Sci.     Publication Date:  2014 Aug 
Date Detail:
Created Date:  2014-8-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014. Published by Elsevier Inc.
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