Document Detail


Effects of an intravenous bolus calcium injection on glomerular filtration rate and electrolyte excretion in the kidney in conscious pigs.
MedLine Citation:
PMID:  3983788     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This paper reports the changes observed in the concentration of various constituents of plasma and in their excretion in the urine after a bolus intravenous injection of 2,2 mM calcium gluconate into conscious pigs weighing 20 kg. In the plasma, both ionic and total calcium concentrations increased but returned to normal within 35 minutes, while sodium, potassium and inorganic phosphate did not change significantly. In the kidney, the urine volume, glomerular filtration rate (GFR) and fractional sodium excretion increased slightly during the first 10 minutes but became significantly depressed later. Potassium and phosphate levels decreased, the latter significantly, while the calcium concentration increased significantly and only returned to normal after 70 minutes. These results suggest that since the disturbances in urinary volume, GFR and fractional phosphate excretion persist after both the plasma calcium and urinary calcium levels have returned to normal, factors other than these calcium values may be responsible for changes in the former measurements.
Authors:
H Maier; G G Járos; R van Hoorn-Hickman; A Hall
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde     Volume:  67     ISSN:  0256-9574     ISO Abbreviation:  S. Afr. Med. J.     Publication Date:  1985 Mar 
Date Detail:
Created Date:  1985-05-13     Completed Date:  1985-05-13     Revised Date:  2014-09-12    
Medline Journal Info:
Nlm Unique ID:  0404520     Medline TA:  S Afr Med J     Country:  SOUTH AFRICA    
Other Details:
Languages:  eng     Pagination:  343-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Absorption
Animals
Calcium / blood*,  urine
Calcium Gluconate / pharmacology*
Electrolytes / urine*
Female
Glomerular Filtration Rate / drug effects*
Gluconates / pharmacology*
Phosphates / urine
Potassium / urine
Sodium / urine
Swine
Time Factors
Chemical
Reg. No./Substance:
0/Electrolytes; 0/Gluconates; 0/Phosphates; 9NEZ333N27/Sodium; RWP5GA015D/Potassium; SQE6VB453K/Calcium Gluconate; SY7Q814VUP/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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