Document Detail


Effects of intravenous anesthetics on the human radial artery used as a coronary artery bypass graft.
MedLine Citation:
PMID:  17289478     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Intravenous anesthetics are often used for anesthesia, sedation, and analgesia in the intraoperative and postoperative periods of coronary artery bypass graft (CABG) surgery. This study was designed to investigate the direct effects of intravenous anesthetics on the human radial artery (RA). DESIGN: In vitro, prospective with repeated measures. SETTING: University research laboratory. PARTICIPANTS: RA segments (n = 20) were obtained from CABG surgery patients and were divided into 3- to 4-mm vascular rings. INTERVENTIONS: Using the organ bath technique, the endothelium-independent vasodilatation function was tested in vitro by the addition of cumulative concentrations of thiopental, ketamine, etomidate, and propofol after vasocontraction by phenylephrine in the presence of N(G)-nitro-L-arginine methyl ester (L-NAME) and indomethacin. MEASUREMENTS AND MAIN RESULTS: Thiopental (10(-8) to 10(-4) mol/L), ketamine(10(-8) to 10(-4) mol/L), propofol (10(-8) to 3 x 10(-4) mol/L), and etomidate (10(-8) to 3 x 10(-4) mol/L) caused concentration-dependent vasorelaxation in human RA rings precontracted with phenylephrine in the presence of L-NAME and indomethacin (n = 20, for each drug). The pEC(50) and maximum relaxant effect values of thiopental and ketamine were significantly higher than for etomidate and propofol (p < 0.05). CONCLUSIONS: These findings indicate that thiopental, ketamine, etomidate, and propofol produce concentration-dependent relaxation on RA rings from humans. Thiopental and ketamine are more potent relaxant agents than etomidate and propofol. Intravenous anesthetics may be effective as alternative vasodilators for treatment of intraoperative and postoperative spasm of coronary artery grafts.
Authors:
Sinan Gursoy; Ocal Berkan; Ihsan Bagcivan; Tijen Kaya; Kemal Yildirim; Caner Mimaroglu
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Publication Detail:
Type:  In Vitro; Journal Article     Date:  2006-04-04
Journal Detail:
Title:  Journal of cardiothoracic and vascular anesthesia     Volume:  21     ISSN:  1053-0770     ISO Abbreviation:  J. Cardiothorac. Vasc. Anesth.     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-02-09     Completed Date:  2007-04-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9110208     Medline TA:  J Cardiothorac Vasc Anesth     Country:  United States    
Other Details:
Languages:  eng     Pagination:  41-4     Citation Subset:  IM    
Affiliation:
Department of Anesthesiology, Cumhuriyet University School of Medicine, Sivas, Turkey.
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MeSH Terms
Descriptor/Qualifier:
Analgesics / pharmacology
Anesthetics, Intravenous / pharmacology*
Anti-Inflammatory Agents, Non-Steroidal / administration & dosage
Coronary Artery Bypass*
Dose-Response Relationship, Drug
Enzyme Inhibitors / administration & dosage
Etomidate / pharmacology
Female
Humans
Indomethacin / administration & dosage
Ketamine / pharmacology
Male
Middle Aged
NG-Nitroarginine Methyl Ester / administration & dosage
Phenylephrine / administration & dosage
Propofol / pharmacology
Prospective Studies
Radial Artery / drug effects*
Thiopental / pharmacology
Vasoconstriction / drug effects
Vasoconstrictor Agents / administration & dosage
Vasodilation / drug effects*
Chemical
Reg. No./Substance:
0/Analgesics; 0/Anesthetics, Intravenous; 0/Anti-Inflammatory Agents, Non-Steroidal; 0/Enzyme Inhibitors; 0/Vasoconstrictor Agents; 2078-54-8/Propofol; 33125-97-2/Etomidate; 50903-99-6/NG-Nitroarginine Methyl Ester; 53-86-1/Indomethacin; 59-42-7/Phenylephrine; 6740-88-1/Ketamine; 76-75-5/Thiopental

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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