| Effects of intravenous amlodipine on coronary hemodynamics in subjects with angiographically normal coronary arteries. | |
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MedLine Citation:
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PMID: 12021583 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of the current study was to assess the ability of amlodipine to dilate the coronary vessels in subjects with angiographically normal coronary arteries and normal left ventricular function. Ten patients, six women and four men (mean age 48 +/- 14 years, range 25-67 years) were enrolled. Coronary flow velocity and coronary perfusion pressure were invasively measured at baseline, during intracoronary adenosine (1-mg bolus) and at 5, 15, and 30 min following IV amlodipine (10 or 20 mg). Quantitative coronary angiography was performed at baseline and at 5, 15, and 30 min after amlodipine. Coronary cross-sectional area and mean coronary flow velocity progressively increased after amlodipine administration, resulting in an average increase in coronary flow at 30 min of 76%. On an individual basis, all patients but one showed a consistent trend toward a progressive coronary vasodilator effect of amlodipine over time. The peak effect of amlodipine on baseline mean coronary flow velocity was 43 +/- 12% that of adenosine. This is the first clinical study demonstrating that the IV administration of amlodipine produces a powerful coronary vasodilatation in subjects with angiographically normal coronary arteries and normal ventricular function, besides its known systemic vasodilating effects. The coronary vasodilating properties of amlodipine are particularly expressed at the microcirculatory level. |
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Authors:
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Danilo Neglia; Michela Gallopin; Paolo Marraccini; Ignazio Simonetti; Mauro Micalizzi; Alberto Macerata; Mario Marzilli; Antonio L'Abbate |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Validation Studies |
Journal Detail:
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Title: Journal of cardiovascular pharmacology Volume: 39 ISSN: 0160-2446 ISO Abbreviation: J. Cardiovasc. Pharmacol. Publication Date: 2002 Jun |
Date Detail:
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Created Date: 2002-05-21 Completed Date: 2002-10-24 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7902492 Medline TA: J Cardiovasc Pharmacol Country: United States |
Other Details:
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Languages: eng Pagination: 884-91 Citation Subset: IM |
Affiliation:
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Consiglio Nazionale delle Ricerche (CNR), Institute of Clinical Physiology, Pisa, Italy. dneglia@ifc.pi.cnr.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine
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pharmacology Adult Aged Amlodipine / adverse effects, pharmacology* Analysis of Variance Blood Flow Velocity / drug effects, physiology Coronary Angiography / drug effects*, statistics & numerical data Coronary Vessels / drug effects*, physiology Female Hemodynamics / drug effects, physiology Humans Infusions, Intravenous Male Middle Aged Vasodilator Agents / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Vasodilator Agents; 58-61-7/Adenosine; 88150-42-9/Amlodipine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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