Document Detail

Effects of intraperitoneal levobupivacaine on pain after laparoscopic cholecystectomy: a prospective, randomized, double-blinded study.
MedLine Citation:
PMID:  20127533     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: We aimed to determine the effects of intraperitoneal administration of levobupivacaine on pain after laparoscopic cholecystectomy in a prospective, randomized, double-blinded, placebo-controlled trial. METHODS: In all patients, infiltration of levobupivacaine 0.25% (15 mL) was used prior to skin incisions for trocar insertion. After pneumoperitoneum was achieved, patients were allocated randomly to receive intraperitoneally either 40 mL of 0.25% levobupivacaine (LB group, n=20) or normal saline (NS group, n=20) under direct vision into the hepatodiaphragmatic lodge and above the gallbladder. Data of intraoperative variables, postoperative pain relief, rescue analgesic consumption, side effects, and patient satisfaction were followed in both groups. RESULTS: The postoperative pain scores were significantly lower in the first half-hour period in the LB group than in the NS group (p<0.05). However, the incidence of right shoulder pain was not significantly different between the LB group (10%) and NS group (15%). The mean dose of meperidine consumption and the number of patients needing rescue meperidine were significantly lower in the LB group than in the NS group (p<0.05). Significantly lower vomiting incidence and increased patient satisfaction were determined in the LB group compared to the NS group (p<0.05). CONCLUSION: Intraperitoneal administration of 40 mL levobupivacaine 0.25% given immediately after pneumoperitoneum into the hepatodiaphragmatic lodge and above the gallbladder demonstrated useful effects on postoperative pain relief after laparoscopic cholecystectomy, especially in the early postoperative period, and reduced postoperative rescue analgesic requirement, with excellent patient satisfaction. There were no LB-related complications or side effects.
I?ik Alper; Sezgin Ulukaya; Volkan Ertu?rul; Ozer Makay; Meltem Uyar; Taner Balcio?lu
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  A?r? : A?r? (Algoloji) Derne?i'nin Yay?n organ?d?r = The journal of the Turkish Society of Algology     Volume:  21     ISSN:  1300-0012     ISO Abbreviation:  Agri     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2010-02-03     Completed Date:  2010-04-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9426197     Medline TA:  Agri     Country:  Turkey    
Other Details:
Languages:  eng     Pagination:  141-5     Citation Subset:  IM    
Department of Anesthesiology and Reanimation, Ege University, Faculty of Medicine, Izmir, Turkey.
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MeSH Terms
Anesthetics, Local / therapeutic use
Bupivacaine / therapeutic use*
Cholecystectomy / methods*
Double-Blind Method
Laparoscopy / methods*
Meperidine / therapeutic use
Metoclopramide / therapeutic use
Middle Aged
Pain, Postoperative / drug therapy*,  psychology
Patient Satisfaction
Prospective Studies
Reg. No./Substance:
0/Anesthetics, Local; 2180-92-9/Bupivacaine; 364-62-5/Metoclopramide; 57-42-1/Meperidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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