Document Detail

Effects of intraperitoneal albumin on systemic and cerebral hemodynamics in a Swine model of acute liver failure.
MedLine Citation:
PMID:  21524179     Owner:  NLM     Status:  In-Data-Review    
ABSTRACT Background: Currently, albumin dialysis is the most widely used nonbiological liver support system. We hypothesized that direct peritoneal albumin exposure in the peritoneal cavity would stabilize blood flow and prevent liver and brain injury, in the same way that had previously been seen with extracorporeal albumin dialysis systems. Materials and Methods: Fourteen Landrace pigs (weight 25-30 kg) underwent 70% right hepatectomy and were randomly assigned into a control (C, n = 7) and an intraperitoneal albumin treated group (A, n = 7). The systemic, cerebral, and pulmonary hemodynamic parameters of the animals were recorded at 0, 6, 9, and 12 hr following reperfusion of the liver remnant. Results: Mean arterial blood pressure, cardiac output, and stroke volume were significantly higher in group A at the end of the experiment. Significantly higher mean intracranial pressure (ICP) values were observed in group C compared to group A, both at 9 hr (21.3 ± 5.2 versus 14.1 ± 3.5 mmHg, p < .0005) and 12 hr (23 ± 4.3 versus 11 ± 3.5 mmHg, p < .0005). On the contrary, cerebral perfusion pressure (CPP) remained stable in albumin-treated groups after the sixth postreperfusion hour. Mean pulmonary artery pressure and pulmonary vascular resistance (PVR) were significantly lower in group A compared to group C at 12 hr, while pulmonary capillary wedge pressure (PCWP) stabilized in albumin-treated animals. Conclusions: This study provides the first evidence that intraperitoneal albumin may be able to attenuate systemic, pulmonary, and cerebral hemodynamic disturbances associated with acute liver failure.
Aliki Tympa; Constantinos Nastos; George Defterevos; Apostolos Papalois; Konstantinos Kalimeris; Georgia Kostopanagiotou; Ioannis Vassiliou; Vassilios Smyrniotis; Nikolaos Arkadopoulos
Related Documents :
21698339 - In situ self-assembly of mild chemical reduction graphene for three-dimensional archite...
12831419 - Helium-oxygen therapy for pediatric acute severe asthma requiring mechanical ventilation.
6206009 - Effect of isovolemic hemodilution on oxygen supply and electrocorticogram in cat brain ...
637999 - Impairment of oxygen transfer in the lung by increasing oxygen concentration during hal...
6446289 - Oxygen consumption and substrate uptake of the hypertrophied rat heart in situ.
7459189 - Intravascular mixed venous oxygen tension monitoring. an analysis of electrode performa...
9146659 - Periurethral collagen injection for the treatment of urinary incontinence in children.
1629059 - Spontaneous resolution of pulmonary edema caused by short periods of cyclic overinflation.
24474139 - Histotripsy-induced cavitation cloud initiation thresholds in tissues of different mech...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of investigative surgery : the official journal of the Academy of Surgical Research     Volume:  24     ISSN:  1521-0553     ISO Abbreviation:  J Invest Surg     Publication Date:  2011  
Date Detail:
Created Date:  2011-04-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8809255     Medline TA:  J Invest Surg     Country:  England    
Other Details:
Languages:  eng     Pagination:  129-33     Citation Subset:  IM    
1Fourth Department of Surgery, Attikon University Hospital, Athens, Greece.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  A novel experimental animal model of arterial stenosis based on endovascular radiofrequency energy a...
Next Document:  The rabbit as an animal model for proctology research: anatomical and histological description.