Document Detail

Effects of intranasal histamine on the cough reflex in subjects with allergic rhinitis.
MedLine Citation:
PMID:  16204792     Owner:  NLM     Status:  MEDLINE    
In the present study we investigated the effects of nasal histamine on the intensity of coughing and the effects of intensified nasal breathing following nasal histamine on cough sensitivity (CS) in 14 subjects with seasonal allergic rhinitis. The study consisted of two parts performed one week apart. First, baseline CS to capsaicin was determined, followed by intranasal histamine challenge (4 mg/ml, 0.1 ml) and the count of the number of coughs to inhaled capsaicin on the background of most intensive nasal symptoms (sneezing, itching, rhinorrhea, and nasal blockage) evoked by histamine. In the second part, CS was determined after intranasal histamine followed by 10 min of intensified nasal breathing through the nose or mouth in a randomized order at 2-day intervals. The number of coughs induced after intranasal histamine was significantly higher, compared with intranasal saline, [9 (7-12) vs. 4.5 (4-6), P<0.001]. CS also was significantly increased after nasal histamine, but nasal intensified breathing failed to cause any changes in CS. We conclude that stimulation of nasal mucosa with histamine enhanced the cough response in subjects with allergic rhinitis.
J Plevkova; M Brozmanova; R Pecova; M Tatar
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society     Volume:  56 Suppl 4     ISSN:  1899-1505     ISO Abbreviation:  J. Physiol. Pharmacol.     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-10-05     Completed Date:  2007-12-06     Revised Date:  2008-05-19    
Medline Journal Info:
Nlm Unique ID:  9114501     Medline TA:  J Physiol Pharmacol     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  185-95     Citation Subset:  IM    
Department of Pathophysiology, Jessenius Medical School, Comenius University, Martin, Slovakia.
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MeSH Terms
Administration, Inhalation
Administration, Intranasal
Capsaicin / administration & dosage
Cough / etiology*,  physiopathology
Dose-Response Relationship, Drug
Histamine / administration & dosage*
Nasal Mucosa / innervation
Nasal Provocation Tests / methods*
Nebulizers and Vaporizers
Neurons, Afferent / drug effects
Reflex / drug effects*
Rhinitis, Allergic, Seasonal / complications*,  physiopathology
Reg. No./Substance:
0/Aerosols; 404-86-4/Capsaicin; 51-45-6/Histamine

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