Document Detail

Effects of intranasal ZnSO4 irrigation on olfactory and trigeminal cues.
MedLine Citation:
PMID:  8190797     Owner:  NLM     Status:  MEDLINE    
Intranasal irrigation with ZnSO4 solutions is used for experimental induction of anosmia. It is, however, unknown whether the trigeminal nerve is affected by the treatment. One day after irrigation (concentrations investigated were between 0.05-1%) the ability of food finding, an olfactory cue, was decreased in a concentration-dependent manner. The trigeminal effect was investigated from a reflexively induced decrease in respiratory rate due to n-propanol exposure. No impairment occurred at 1% ZnSO4. Anosmia was also seen 2-3 h after an irrigation with solutions of 0.05-1% ZnSO4. At the same time, 0.2 and 1% solutions in themselves decreased the respiratory rate due to reflexes from the upper and lower respiratory tract. A conspicuous systemic effect can be ruled out as the Zn++ antidote, CaNa2EDTA, had no effect on the decrease. A direct activation of the trigeminal nerve due to a reaction with a thiol group may explain the effect from the upper airways.
L F Hansen; M Hammer; S H Petersen; G D Nielsen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Physiology & behavior     Volume:  55     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  1994 Apr 
Date Detail:
Created Date:  1994-06-17     Completed Date:  1994-06-17     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  699-704     Citation Subset:  IM    
National Institute of Occupational Health, Copenhagen, Denmark.
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MeSH Terms
1-Propanol / pharmacology
Appetitive Behavior / drug effects,  physiology
Dose-Response Relationship, Drug
Olfactory Mucosa / innervation*
Olfactory Nerve / drug effects*,  physiology
Pulmonary Ventilation / drug effects,  physiology
Reaction Time / drug effects,  physiology
Smell / drug effects*,  physiology
Sulfates / pharmacology*
Trigeminal Nerve / drug effects*,  physiology
Zinc Compounds / pharmacology*
Zinc Sulfate
Reg. No./Substance:
0/Sulfates; 0/Zinc Compounds; 71-23-8/1-Propanol; 7733-02-0/Zinc Sulfate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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