Document Detail


Effects of intramuscular omeprazole on gastric acid secretion in horses over a twenty-four hour period.
MedLine Citation:
PMID:  10696294     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of intramuscular (i.m.) omeprazole (0.25 or 1.0 mg/kg bwt; LD and HD), respectively, on volume, total acid output (TAO) and pH of the gastric juice was studied during 24 h in 5 horses with a chronically implanted gastric cannula. Whether secretion in controls was basal or stimulated with pentagastrin (8 micrograms/kg bwt/h), volume (NS) and TAO (P < 0.01, NS) gradually decreased and pH increased (P < 0.05, NS). Omeprazole significantly reduced the average basal TAO by 49 +/- 6% (LD) and 88 +/- 3% (HD) and the stimulated TAO by 64 +/- 2% and 97 +/- 1%. Basal pH in controls was 2.1-4.2 and after omeprazole treatment, pH 2.8-4.1 (LD) and 2.4-6.6 (HD). After stimulation, the corresponding pH values were 2.6-3.3, 3.9-4.9 and 5.4-7.2. The biological availability of omeprazole was 70-80%. Due to the simplicity of the administration technique and the higher biological availability, intramuscular administration may offer a practical and less expensive way of treating gastric ulcers in horses.
Authors:
A Sandin; F M Andrews; J A Nadeau; T J Doherty; G Nilsson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Equine veterinary journal. Supplement     Volume:  -     ISSN:  -     ISO Abbreviation:  Equine Vet J Suppl     Publication Date:  1999 Apr 
Date Detail:
Created Date:  2000-03-24     Completed Date:  2000-03-24     Revised Date:  2007-05-18    
Medline Journal Info:
Nlm Unique ID:  9614088     Medline TA:  Equine Vet J Suppl     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  50-3     Citation Subset:  IM    
Affiliation:
Department of Animal Physiology, Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences, Uppsala, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Ulcer Agents / administration & dosage,  blood,  pharmacology*
Area Under Curve
Biological Availability
Circadian Rhythm
Female
Gastric Acid / secretion*
Gastric Juice / drug effects*,  secretion
Horses / metabolism,  physiology*
Hydrogen-Ion Concentration
Injections, Intramuscular / veterinary
Male
Omeprazole / administration & dosage,  blood,  pharmacology*
Reference Values
Chemical
Reg. No./Substance:
0/Anti-Ulcer Agents; 73590-58-6/Omeprazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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