Document Detail

Effects of intraluminal hydrostatic pressure on L-methionine absorption in the obstructed small intestine of the rat.
MedLine Citation:
PMID:  3953959     Owner:  NLM     Status:  MEDLINE    
The effects of elevated intraluminal hydrostatic pressure on the active absorption of the amino acid selenium 75 L-methionine has been analyzed in the normal and obstructed small intestine. An intestinal loop of defined position and length was included in a recircling perfusion system from which the elimination rate of the radiolabeled amino acid was measured. Preset pressure levels within the system were maintained by a servo-controlled unit, which added or subtracted volume to keep the pressure constant. The rate of amino acid elimination increased when the nonobstructed loop was subjected to a pressure of 10 cm H2O but decreased when exposed to 20cm H2O. Using a loop of intestine subjected to 48 hours of obstruction, amino acid elimination was greatly retarded compared with that of the nonobstructed loop. By increasing the intraluminal pressure to 10 and 20 cm H2O, the elimination rate increased, equalling that of the nonobstructed gut. The results suggest that intestinal obstruction per se decreases active absorption secondary to impaired intestinal viability. Moderately increased intraluminal pressure adds a driving force to L-methionine absorption, the mechanism of which is obscure.
L Enochsson; G Nylander
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of surgery     Volume:  151     ISSN:  0002-9610     ISO Abbreviation:  Am. J. Surg.     Publication Date:  1986 Mar 
Date Detail:
Created Date:  1986-04-11     Completed Date:  1986-04-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370473     Medline TA:  Am J Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  391-6     Citation Subset:  AIM; IM    
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MeSH Terms
Disease Models, Animal
Evaluation Studies as Topic
Hydrostatic Pressure*
Ileal Diseases / metabolism
Ileum / metabolism
Intestinal Absorption*
Intestinal Obstruction / metabolism*
Intestine, Small / metabolism*
Methionine / metabolism*
Radioisotopes / diagnostic use
Rats, Inbred Strains
Regression Analysis
Selenium / diagnostic use
Reg. No./Substance:
0/Radioisotopes; 63-68-3/Methionine; 7782-49-2/Selenium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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